Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio.

Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Research Abstract Details 

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Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Abstract Text:

The enantiomers of hexobarbital, designated as S(+)-HB and R(-)-HB, were administered intra-arterially to rats in a dose of 25 mg X kg-1. Blood pharmacokinetics of the parent compound and two metabolites as well as urinary excretion of three major metabolites were studied. Using previously obtained data following oral administration of S(+)-HB and R(-)-HB two different methods for calculation of the hepatic extraction ratio (E) were compared. The metabolite profile in the urine after intra-arterial administration was not basically different from corresponding data on oral administration. The clearance of low-dose, intra-arterially administered S(+)-HB is useful as an indicator of hepatic blood flow in the rat.

Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Publishing Authors By Initials

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

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Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutisch weekblad. Scientific edition

VOLUME: 8

Page Numbers: 139-44

Journal Abbreviation:

ISSN: 0167-6555

DAY: 25

MONTH: Apr

YEAR: 1986

Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Information

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LANGUAGE: eng

NlmUniqueID: 7907992

Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

MESH TERMS: metabolism

Chemical & Substance for Abstract: Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Information

Substance Name: Hexobarbital

Registry Number: 56-29-1

Grant and Affiliation Information for Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio.

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Country: NETHERLANDS

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MEDLINETA: Pharm Weekbl Sci

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