Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy.

Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Research Abstract Details 

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Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Abstract Text:

M I Filipe,A Sandey,J Ma,

The expression of two intestinal mucin-associated antigens large intestine mucin antigen (LIMA) and small intestine mucin antigen (SIMA) were investigated by indirect immunoperoxidase staining of rectal mucosa from patients suffering from ulcerative colitis with (n = 6) and without (n = 31) associated carcinoma and in noncolitic controls (n = 40). The aim was to assess the relationship between antigen patterns and malignant change. SIMA, which is localised predominantly in the small intestine, is virtually undetectable in the normal adult colonic mucosa. However, this antigen is present in the foetal colon and colonic carcinoma. LIMA is expressed in normal colonic mucosa, but absent from the small intestine. LIMA staining patterns were not significantly different among the three groups. In contrast, expression of SIMA was significantly higher in the patients who had developed carcinoma (6/6) than in the noncancer group (7/71) (P less than 0.001). The presence of SIMA was also significantly related to areas of dysplasia compared to normal (P = .03) or inflammation (P less than .05), but it did not differ from mucosa showing "indefinite" atypia. The finding of 31% SIMA-positive biopsies associated with severe inflammation in colitis with active disease, but no evidence of malignancy, is difficult to explain at the present stage. A followup study would be necessary to determine its significance. Perhaps the most important finding is the increased frequency of SIMA-positive foci in histologically normal mucosa in carcinoma patients compared with the noncancer group (P less than .001), suggesting a field change. These observations may be prove useful for the identification of patients who may be at risk of developing carcinoma.

Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Publishing Authors By Initials

MI Filipe,A Sandey,J Ma,

For similar digestive system: gastrointestinal tract: intestines: intestine, large: rectum research abstracts see: digestive system: gastrointestinal tract: intestines: intestine, large: rectum research

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Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Human pathology

VOLUME: 19

Page Numbers: 671-81

Journal Abbreviation: Hum. Pathol.

ISSN: 0046-8177

DAY: 1

MONTH: Jun

YEAR: 1988

Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Information

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LANGUAGE: eng

NlmUniqueID: 9421547

Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Keywords Mesh Terms:

KEYWORDS: Rectum

MESH TERMS: pathology

Chemical & Substance for Abstract: Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy. Information

Substance Name: gastro-intestinal mucus-associated antig

Registry Number: 0

Grant and Affiliation Information for Intestinal mucin antigens in ulcerative colitis and their relationship with malignancy.

AFFILIATION: Department of Histopathology, United Medical School of Guy's Hospital, London Bridge, England.

Country: UNITED STATES

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MEDLINETA: Hum Pathol

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