Intestinal morphogenesis.

Intestinal morphogenesis. Research Abstract Details 

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Intestinal morphogenesis. Abstract Text:

Deborah C Rubin,

PURPOSE OF REVIEW: The molecular basis of endoderm differentiation and interaction with mesoderm to generate the mature intestine has been the focus of intensive investigation. Signaling pathways relevant to organogenesis may be recapitulated during oncogenesis. This review highlights recent studies of endoderm specification, differentiation and formation of the gut tube, the ontogeny of regional differentiation along the anterior-posterior and crypt-villus axes, and mechanisms of epithelial differentiation and epithelial-mesenchymal interactions during gut morphogenesis. RECENT FINDINGS: Model organisms include zebrafish, Xenopus, Drosophila and the mouse. Fibroblast growth factors play critical roles in early endoderm differentiation and anterior-posterior patterning, and retinoids regulate left-right asymmetry and gut looping/rotation. Embryoid bodies derived from embryonic stem cells recapitulate many aspects of gut epithelial morphogenesis. Novel regulators of epithelial cell differentiation and epithelial-mesenchymal interactions have been identified (e.g. Mtgr1), and several known genes modulate these processes (e.g. PPARbeta/delta, Ptk6, GATA4). The role of Bmp, Hh and wnt signaling in morphogenesis continues to be elucidated. SUMMARY: The complex process of intestinal morphogenesis involves interactions among multiple signaling pathways. Studies of morphogenesis are critical for elucidating the molecular basis of congenital gut defects and provide novel insight into intestinal oncogenic processes.

Intestinal morphogenesis. Publishing Authors By Initials

DC Rubin,

For similar physiological processes: growth and development: morphogenesis research abstracts see: physiological processes: growth and development: morphogenesis research

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Intestinal morphogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in gastroenterology

VOLUME: 23

Page Numbers: 111-4

Journal Abbreviation: Curr. Opin. Gastroenterol.

ISSN: 0267-1379

DAY: 3

MONTH: Mar

YEAR: 2007

Intestinal morphogenesis. Information

Number of References: 30

LANGUAGE: eng

NlmUniqueID: 8506887

Intestinal morphogenesis. Keywords Mesh Terms:

KEYWORDS: Morphogenesis

MESH TERMS: genetics

Chemical & Substance for Abstract: Intestinal morphogenesis. Information

Substance Name: Hedgehog Proteins

Registry Number: 0

Grant and Affiliation Information for Intestinal morphogenesis.

AFFILIATION: Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. drubin@wustl.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK61216

ACRONYM: DK

MEDLINETA: Curr Opin Gastroenterol

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