Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy.

Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Research Abstract Details 

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Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Abstract Text:

Jarod C Finlay,Timothy C Zhu,Andreea Dimofte,Diana Stripp,S Bruce Malkowicz,Theresa M Busch,Stephen M Hahn,

The in vivo fluorescence emission from human prostates was measured before and after motexafin lutetium (MLu)-mediated photodynamic therapy (PDT). A single side-firing optical fiber was used for both the delivery of 465 nm light-emitting diode excitation light and the collection of emitted fluorescence. It was placed interstitially within the prostate via a closed transparent plastic catheter. Fitting of the collected fluorescence emission spectra using the known fluorescence spectrum of 1 mg/kg MLu in an intralipid phantom yields a quantitative measure of the local MLu concentration. We found that an additional correction factor is needed to account for the reduction of the MLu fluorescence intensity measured in vivo due to strong optical absorption in the prostate. We have adopted an empirical correction formula given by C = (3.1 cm(-1)/micro's) exp (microeff x 0.97 cm), which ranges from approximately 3 to 16, with a mean of 9.3 +/-4.8. Using a computer-controlled step motor to move the probe incrementally along parallel tracks within the prostate we can determine one-dimensional profiles of the MLu concentration. The absolute MLu concentration and the shape of its distribution are confirmed by ex vivo assay and by diffuse absorption measurements, respectively. We find significant heterogeneity in photosensitizer concentration within and among five patients. These variations occur over large enough spatial scales compared with the sampling volume of the fluorescence emission that mapping the distribution in three dimensions is possible.

Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Publishing Authors By Initials

JC Finlay,TC Zhu,A Dimofte,D Stripp,SB Malkowicz,TM Busch,SM Hahn,

For similar investigative techniques: chemistry, analytical: photometry: luminescent measurements: fluorometry: spectrometry, fluorescence research abstracts see: investigative techniques: chemistry, analytical: photometry: luminescent measurements: fluorometry: spectrometry, fluorescence research

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MEDLINE DATE:

Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Photochemistry and photobiology

VOLUME: 82

Page Numbers: 1270-8

Journal Abbreviation:

ISSN: 0031-8655

DAY: 3

MONTH: 12

YEAR: 2007

Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376425

Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Keywords Mesh Terms:

KEYWORDS: Spectrometry, Fluorescence

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy. Information

Substance Name: motexafin lutetium

Registry Number: 156436-90-7

Grant and Affiliation Information for Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy.

AFFILIATION: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA. finlay@mail.med.upenn.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA109456-01

ACRONYM: CA

MEDLINETA: Photochem Photobiol

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