Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia.

Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Research Abstract Details 

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Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Abstract Text:

T Yamada,Y Tsuboi,M Takahashi,

Complement-activated oligodendroglia (CAOs) are thought to represent complement bearing damaged oligodendroglia for opsonization. The interrelationship between CAOs and amyloid deposits was examined by immunohistochemistry in the parietal lobe of patients with Parkinson's disease, diffuse Lewy body disease, and pallido-nigro-luysial atrophy. In all brains, the anti-C4d antibody stained numerous CAOs. Anti-beta-amyloid protein (anti-A beta) antibody revealed moderate numbers of senile plaques, including some of the classical type. In both the grey and the white matter amyloid deposits were frequently associated with the myelinated axons of CAOs. CAOs were occasionally associated with phagocytosing microglial cells. Immunoelectron microscopy also showed a close relationship between phagocytosing microglia and A beta deposition. On some occasions. A beta deposits were seen in C4d-positive oligodendroglial cell bodies. These results indicate that damaged myelinated axons, which contain accumulated amyloid precursor protein, are the source of A beta, and that CAOs may be initial targets for A beta deposits forming the classical senile plaques.

Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Publishing Authors By Initials

T Yamada,Y Tsuboi,M Takahashi,

For similar nervous system: neuroglia: oligodendroglia research abstracts see: nervous system: neuroglia: oligodendroglia research

PUBMED ID PMID:

MEDLINE DATE: 1997 Sep-Oct

Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Dementia and geriatric cognitive disorders

VOLUME: 8

Page Numbers: 267-72

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Keywords Mesh Terms:

KEYWORDS: Oligodendroglia

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Information

Substance Name: HLA-DR Antigens

Registry Number: 0

Grant and Affiliation Information for Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia.

AFFILIATION: Department of Neurology, Chiba University, Japan.

Country: SWITZERLAND

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MEDLINETA: Dement Geriatr Cogn Disord

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