Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing.

Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Research Abstract Details 

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Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Abstract Text:

Sarah L Kieweg,David F Katz,

Prophylactic efficacy of topical microbicidal drug delivery formulations against HIV may depend upon their abilities to coat and be retained on epithelial surfaces where infection begins. Rheological and surface properties play paramount roles in governing coating. While fundamental fluid mechanical studies of epithelial coating mechanisms have begun, their results have not previously addressed questions of practical value to formulators in the pharmaceutics community. The present theoretical study began this process. We focused upon squeezing flows of seven vaginal gels which are models for future microbicides or a candidate formulation in clinical trials. Each formulation is based upon one of three different macromolecules: cellulose, polyacrylic acid (PAA), or carrageenan. We addressed: (1) properties with greatest influence on squeezing flow; (2) alterations of properties to improve measures of coating dynamics; and (3) effects of polymer concentration and temperature on coating dynamics. We found that yield stresses dominated flows of PAA gels, and that surface slip, while small, significantly influenced coating by cellulose gels. Decreases in consistency, increases in shear-thinning, and increases in temperature led to thinner coatings. Details of altered coating rates depended upon parameter values and time. Specific polymer concentration effects differed between cellulose and PAA gels, though trends were similar.

Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Publishing Authors By Initials

SL Kieweg,DF Katz,

For similar natural sciences: chemistry: chemistry, physical: viscosity research abstracts see: natural sciences: chemistry: chemistry, physical: viscosity research

PUBMED ID PMID:

MEDLINE DATE:

Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of pharmaceutical sciences

VOLUME: 96

Page Numbers: 835-50

Journal Abbreviation:

ISSN: 0022-3549

DAY: 3

MONTH: Apr

YEAR: 2007

Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985195

Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Keywords Mesh Terms:

KEYWORDS: Viscosity

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. Information

Substance Name: carboxypolymethylene

Registry Number: 9007-20-9

Grant and Affiliation Information for Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing.

AFFILIATION: Department of Mechanical Engineering, University of Kansas, Lawrence, Kansas 66045, USA. kieweg@ku.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI48103

ACRONYM: AI

MEDLINETA: J Pharm Sci

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