Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines.

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Research Abstract Details 

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Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Abstract Text:

Laura Mulvey,Alamelu Chandrasekaran,Kai Liu,Sarah Lombardi,Xue-Ping Wang,Karen J Auborn,Leslie Goodwin,

Diindolylmethane (DIM), a biologically active congener of indole-3-carbinol (I3C) derived from cruciferous vegetables, is a promising agent for the prevention of estrogen-sensitive cancers. Both DIM and estrogen affect transcription of genes by binding receptors, such as aryl hydrocarbon receptor (AhR) or estrogen receptors (ER). Gene regulation by DIM and estradiol (E2) can be very complex. While DIM typically binds the AhR, this complex can directly associate with the ER, recruit co-activators that bind to estrogen-responsive promoters, and activate transcription. Alternately, DIM can bind the ER directly. In this study, we have analyzed gene expression using microarray profiling and quantitative real time-polymerase chain reaction in MCF7 breast cancer cells treated with E2 (1 nM) or DIM (25 microM) alone or in combination for 16 h. The interplay of E2 and DIM was reflected in the expression of a subset of genes (<90) in which the combination of E2 and DIM acted either additively or antagonistically to alter gene expression.

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Publishing Authors By Initials

L Mulvey,A Chandrasekaran,K Liu,S Lombardi,XP Wang,KJ Auborn,L Goodwin,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

PUBMED ID PMID:

MEDLINE DATE: 2007 Jan-Feb

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular medicine (Cambridge, Mass.)

VOLUME: 13

Page Numbers: 69-78

Journal Abbreviation: Mol. Med.

ISSN: 1076-1551

DAY: 3

MONTH: 12

YEAR: 2007

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9501023

Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: drug effects

Chemical & Substance for Abstract: Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines. Information

Substance Name: diindolylmethane

Registry Number: 0

Grant and Affiliation Information for Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines.

AFFILIATION: Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA733850

ACRONYM: CA

MEDLINETA: Mol Med

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