Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells.

Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells. Research Abstract Details 

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Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells. Abstract Text:

Kim R Geisinger,Colleen Vrbin,Dana M Grzybicki,P Wagner,A Julian Garvin,Stephen S Raab,Kim R Geisinger,Colleen Vrbin,Dana M Grzybicki,P Wagner,A Julian Garvin,Stephen S Raab,Kim R Geisinger,Colleen Vrbin,Dana M Grzybicki,P Wagner,A Julian Garvin,Stephen S Raab,

We studied interobserver variability in the proportions of human papillomavirus (HPV)-positive results for atypical squamous cells of undetermined significance (ASCUS) and atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) diagnoses among 5 pathologists from the me laboratory during a 2-year period. These proportions were compared with individual pathologist's ASCUS/squamous intraepithelial lesion (SIL) ratios.Of 1,299 ASCUS diagnoses, 32.3% had HPV testing; 49.4% were HPV+. Positive findings by individual pathologists ranged from 38% to 67% (P = .057). There was a difference in the proportions of highrisk HPV results for individual pathologists (P < .001). For the pathologist who diagnosed 38% (23/61) of mples as HPV+, the ASCUS/SIL was 0.58; the pathologist who diagnosed 67% (28/42) as HPV+ had a ratio of 1.02. Of the ASC-H diagnoses, 32.9% were tested for HPV; 63% (46/73) were positive. Although the HPV+ proportion by pathologist ranged from 54% to 83%, no significant differences were identified.Within the me laboratory, interobserver variability exists in the proportions of HPV positivity for ASCUS and ASC-H interpretations.

Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells. Publishing Authors By Initials

KR Geisinger,C Vrbin,DM Grzybicki,P Wagner,AJ Garvin,SS Raab,KR Geisinger,C Vrbin,DM Grzybicki,P Wagner,AJ Garvin,SS Raab,KR Geisinger,C Vrbin,DM Grzybicki,P Wagner,AJ Garvin,SS Raab,

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Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of clinical pathology

VOLUME: 128

Page Numbers: 1010-4

Journal Abbreviation: Am. J. Clin. Pathol.

ISSN: 0002-9173

DAY: 20

MONTH: Dec

YEAR: 2007

Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells. Information

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LANGUAGE: eng

NlmUniqueID: 370470

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Grant and Affiliation Information for Interobserver variability in human papillomavirus test results in cervicovaginal cytologic specimens interpreted as atypical squamous cells.

AFFILIATION: Departments of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC.

Country: United States

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MEDLINETA: Am J Clin Pathol

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