International studies in dementia with particular emphasis on populations of African origin.

International studies in dementia with particular emphasis on populations of African origin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

International studies in dementia with particular emphasis on populations of African origin. Abstract Text:

Hugh C Hendrie,Jill Murrell,Sujuan Gao,Fredrick W Unverzagt,Adesola Ogunniyi,Kathleen S Hall,

Epidemiologic studies on dementia generally have 2 major interacting objectives: descriptive, where rates of dementia and Alzheimer Disease (AD) are calculated for communities and selected populations, and analytic, which attempt to explain the observed phenotypic variations in communities and populations by identifying disease risk factors. The public health benefits derived from descriptive studies are exemplified by the recent published review of the global prevalence of dementia under the auspices of Alzheimer Disease International. This review emphasized the enormous and growing burden associated with dementia particularly for countries in the developing world and outlined strategies to influence policy making, planning, and healthcare allocation. One interesting feature of descriptive studies on dementia is that although the few epidemiologic studies conducted in Africa suggest that rates of dementia and AD are relatively low, rates of AD and dementia have been reported to be relatively high for African Americans. The Indianapolis-Ibadan Dementia Project has reported that the incidence rates for AD and dementia in Yoruba are less than half the incidence rates for AD and dementia in African Americans. Analytic studies are now underway to identify risk factors that may account for these rate differences. The risk factor model being applied, attempts to identify not only putative genetic and environmental factors but also their interactions. So far the major findings have included: apolipoprotein E e4, a major risk factor for AD in most populations, is also a risk factor for AD in African Americans but not for Yoruba; African Americans are at higher risk not only for AD, but also for diseases associated with increased cardiovascular risk such as hypertension, diabetes, and metabolic syndrome; African Americans have higher rates of hypercholesterolemia than Yoruba: there is an interaction between apolipoprotein E e4, cholesterol, and AD risk in both Yoruba and African Americans. We eventually hope to create a risk factor model that will not only account for the dementia rate differences between Yoruba and African Americans, but also help explain dementia rates in other developing and developed countries.

International studies in dementia with particular emphasis on populations of African origin. Publishing Authors By Initials

HC Hendrie,J Murrell,S Gao,FW Unverzagt,A Ogunniyi,KS Hall,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

International studies in dementia with particular emphasis on populations of African origin. Journal Published:

PUBLICATION TYPE: Review

Journal: Alzheimer disease and associated disorders

VOLUME: 20

Page Numbers: S42-6

Journal Abbreviation:

ISSN: 0893-0341

DAY: 3

MONTH: 12

YEAR: 2007

International studies in dementia with particular emphasis on populations of African origin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8704771

International studies in dementia with particular emphasis on populations of African origin. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: International studies in dementia with particular emphasis on populations of African origin. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for International studies in dementia with particular emphasis on populations of African origin.

AFFILIATION: Department of Psychiatry, and Center for Aging Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. hhendri@iupui.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Alzheimer Dis Assoc Disord

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

International studies in dementia with particular emphasis on populations of African origin Related Publications

• A comparison of Ki67 immunostaining and nucleolar organiser region staining in non-Hodgkin's lymphoma. P. A. Hall, J. Crocker, A. Watts, A. G. Stansfeld. Histopathology 1988; 12; 373-381 &.
• A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
• A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.
• A summary of recommendations for the management of opioid dependence: the quality assurance in the treatment of drug dependence project.
• AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0.
• Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1.
• Activin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitro.
• Editorial.
• Effect of cartilage oligomeric matrix protein on mesenchymal chondrogenesis in vitro.
• Effect of nutrition on the LH response to calf removal and GnRH.
• Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2.
• Gene expression profiling following BMP-2 induction of mesenchymal chondrogenesis in vitro.
• In-situ hydration studies using multi-angle energy-dispersive diffraction.
• International studies in dementia with particular emphasis on populations of African origin.
• Investigations of the incidence of bovine trichomoniasis in nevada and of the efficacy of immunizing cattle with vaccines containing Tritrichomonas foetus.
• Is ultrasound useful for evaluating paediatric inflammatory neck masses?
• Laparoscopic transfer of ovine and cervine embryos using the transpic technique.
• Nonword repetition skills in young children who do and do not stutter.
• Oxygen cathode measurements and radiation response in tumour-bearing mice treated with misonidazole.
• Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade.
• Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16.
• Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.
• Spontaneous formation of annular structures observed in molecular dynamics simulations of polyglutamine peptides.
• Systems approaches to biological rhythms in Drosophila.
• The effectiveness of methadone maintenance treatment: an overview.
• The use of derivative and least-squares methods to analyse a polypharmaceutical product by UV spectrophotometry.
• Validation analysis of informant's ratings of cognitive function in African Americans and Nigerians.
• Viral Load and Neuropsychological Functioning in HIV Seropositive Individuals:A Preliminary Descriptive Study.
• [In Process Citation]
• [In Process Citation]