Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Research Abstract Details 

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Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Abstract Text:

Davide Tampellini,Jordi ,Reisuke H Takahashi,Feng Li,Michael T Lin, Almeida,Gunnar K Gouras,

Immunotherapy against beta-amyloid peptide (Abeta) is a leading therapeutic direction for Alzheimer disease (AD). Experimental studies in transgenic mouse models of AD have demonstrated that Abeta immunization reduces Abeta plaque pathology and improves cognitive function. However, the biological mechanisms by which Abeta antibodies reduce amyloid accumulation in the brain remain unclear. We provide evidence that treatment of AD mutant neuroblastoma cells or primary neurons with Abeta antibodies decreases levels of intracellular Abeta. Antibody-mediated reduction in cellular Abeta appears to require that the antibody binds to the extracellular Abeta domain of the amyloid precursor protein (APP) and be internalized. In addition, treatment with Abeta antibodies protects against synaptic alterations that occur in APP mutant neurons.

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Publishing Authors By Initials

D Tampellini,J ,RH Takahashi,F Li,MT Lin,CG Almeida,GK Gouras,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 18895-906

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 27

MONTH: 04

YEAR: 2007

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: pathology

Chemical & Substance for Abstract: Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. Information

Substance Name: Amyloid Precursor Protein Secretases

Registry Number: EC 3.4.-

Grant and Affiliation Information for Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

AFFILIATION: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS045677

ACRONYM: NS

MEDLINETA: J Biol Chem

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