[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy]

[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Research Abstract Details 

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[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Abstract Text:

S A El'chaninova,N A Koreniak,I V Smagina,L E Pinegin,B Ia Varshavski?,

An influence of intermittent hypoxia (IH) on antioxidant enzymes activity was investigated in 42 patients, aged 48.2 +/- 1.8 years, with 1-2-nd stage of dyscirculatory encephalopathy (DE) in the presence of I-II stage of arterial hypertension (AH). Patients with arterial pressure below 145/85 mmHg receiving basic antihypertensive drugs treatment were included in the study. Before IH, the patients showed increased total oxidant activity (TOA) as well as concentration of thiobarbituric acid reactive substances (TBRS) in blood plasma and reduced activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GP) in erythrocytes comparing to control group (14 healthy subjects). In 27 patients, it was combined with increased peak systolic and peak diastolic blood flow rate in middle cerebral artery according to Doppler examination. After 10 days hypoxia training (60 min daily atmospheric air breathing alternated with 9-10 V% O2 hypoxic mixture breathing), TOA and TBRS were decreased by 39% and 25% respectively, whereas enzymes activity was increased as follows: SOD--by 29%; CAT--by 18%; GP--by 38%. The treatment resulted in reduction of peak systolic and peak diastolic blood flow rate in the meddle cerebral artery, decrease of frequency of headache episodes and in improvement of nighttime sleep and short-term memory. The results demonstrate a possibility for correction of oxidative homeostasis disturbances in patients with DE on the background of AH and can be beneficial for DE prevention and treatment.

[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Publishing Authors By Initials

SA El'chaninova,NA Koreniak,IV Smagina,LE Pinegin,BIa Varshavski?,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsak

VOLUME: 102

Page Numbers: 29-32

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ISSN: 1997-7298

DAY: 31

MONTH: 03

YEAR: 2002

[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Information

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LANGUAGE: rus

NlmUniqueID: 9712194

[Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: [Intermittent hypoxia in the treatment of dyscirculatory encephalopathy] Information

Substance Name: Oxidoreductases

Registry Number: EC 1.-

Grant and Affiliation Information for [Intermittent hypoxia in the treatment of dyscirculatory encephalopathy]

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Country: Russia

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MEDLINETA: Zh Nevrol Psikhiatr Im S S Kor

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