Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary.

Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary. Research Abstract Details 

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Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary. Abstract Text:

Meghan M White,Willis K Samson,

A fragment of intermedin (IMD), IMD17-47, has been shown to antagonize the hypotensive effects of intravenous IMD administration; however, the effects of IMD17-47 have not been studied in other systems such as brain and pituitary gland. IMD17-47 was administered intracerebroventricularly (i.c.v.) into male rats alone or prior to administration of IMD; and blood pressure and food and water intakes measured. Multiple doses of IMD17-47 failed to alter basal blood pressure and heart rate, but did partially reverse the stimulatory effects of IMD given i.c.v. on blood pressure and heart rate. A low dose of IMD17-47 by itself significantly increased basal food and water intake. However, a higher dose of the antagonist did not alter food or water intake compared to control treated rats. No dose of IMD17-47 was able to reverse the inhibitory effects of IMD administered i.c.v. on food and water intake. Furthermore, IMD17-47 failed to significantly alter the inhibitory effects of IMD on growth hormone releasing hormone-stimulated growth hormone release from dispersed anterior pituitary cells in culture. A siRNA molecule designed to compromise IMD production was able to reduce brain IMD levels and did, upon i.c.v. administration, cause increased water drinking in male rats. This tool may provide a better method than the use of the IMD17-47 compound to study the role of endogenous IMD within the CNS and pituitary.

Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary. Publishing Authors By Initials

MM White,WK Samson,

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Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Peptides

VOLUME: 28

Page Numbers: 2171-8

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 11

MONTH: 09

YEAR: 2007

Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary. Information

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LANGUAGE: eng

NlmUniqueID: 8008690

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Grant and Affiliation Information for Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary.

AFFILIATION: Saint Louis University, School of Medicine, Department of Pharmacological and Physiological Science, 1402 S. Grand Boulevard, St. Louis, MO 63104, USA. mwhite44@slu.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL 66023

ACRONYM: HL

MEDLINETA: Peptides

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