Intermediate frequency magnetic fields do not have mutagenic, co-mutagenic or gene conversion potentials in microbial genotoxicity tests.

Intermediate frequency magnetic fields do not have mutagenic, co-mutagenic or gene conversion potentials in microbial genotoxicity tests. Research Abstract Details 

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Intermediate frequency magnetic fields do not have mutagenic, co-mutagenic or gene conversion potentials in microbial genotoxicity tests. Abstract Text:

Satoshi Nakasono,Masateru Ikehata,Minori Dateki,Sachiko Yoshie,Tsukasa Shigemitsu,Tadashi Negishi,

We used bacterial mutation and yeast genotoxicity tests to evaluate the effects of intermediate frequency (IF; 2kHz, 20kHz and 60kHz) magnetic fields (MFs) on mutagenicity, co-mutagenicity and gene conversion. We constructed a Helmholtz type exposure system that generated vertical and sinusoidal IF MFs, such as 0.91mT at 2kHz, 1.1mT at 20kHz and 0.11mT at 60kHz. Mutagenicity, co-mutagenicity and gene conversion assays were performed for each of the three MF exposure conditions. Mutagenicity testing was performed in four strains of Salmonella typhimurium (TA98, TA100, TA1535 and TA1537) and two strains of Escherichia coli (WP2 uvrA and WP2 uvrA/pKM101) to cover a wide spectrum of point mutations. For co-mutagenicity tests, we used four sensitive test strains (TA98, TA100, WP2 uvrA and WP2 uvrA/pKM101) with five chemical mutagens (t-butyl hydroperoxide (BH, a hydroxyl free radical precursor), 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF2) and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG, DNA reactive reagents), benz[a]pyrene (BaP) and 2-aminoanthracene (2AA, DNA reactive promutagens). Gene conversion testing was performed in the yeast test strain, Saccharomyces cerevisiae XD83. We also examined the effects on the repair process of DNA damage by UV irradiation. No statistically significant effects were observed between exposed and control groups in any of the genotoxicity tests, indicating that the IF MFs (0.91mT at 2kHz, 1.1mT at 20kHz or 0.11mT at 60kHz) do not have mutagenic or co-mutagenic potentials for the chemical mutagens tested under these experimental conditions. Our findings also indicate that these IF MFs do not induce gene conversion or affect the repair process of DNA damage in eukaryotic cells.

Intermediate frequency magnetic fields do not have mutagenic, co-mutagenic or gene conversion potentials in microbial genotoxicity tests. Publishing Authors By Initials

S Nakasono,M Ikehata,M Dateki,S Yoshie,T Shigemitsu,T Negishi,

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Intermediate frequency magnetic fields do not have mutagenic, co-mutagenic or gene conversion potentials in microbial genotoxicity tests. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Mutation research

VOLUME: 649

Page Numbers: 187-200

Journal Abbreviation: Mutat. Res.

ISSN: 0027-5107

DAY: 29

MONTH: 09

YEAR: 2007

Intermediate frequency magnetic fields do not have mutagenic, co-mutagenic or gene conversion potentials in microbial genotoxicity tests. Information

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LANGUAGE: eng

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AFFILIATION: EMF Environment Sector, Environmental Science Research Laboratory, Central Research Institute of Electric Power Industry, 1646 Abiko, Abiko-city, Chiba 270-1194, Japan.

Country: Netherlands

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MEDLINETA: Mutat Res

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