Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Research Abstract Details 

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Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Abstract Text:

Manuel Koch,Ulrike May,Stefanie Kuhns,Hauke Drechsler,Nina Adam,Kirsten Hattermann,Stefan Wirtz,Stefan Rose-John, Scheller,Manuel Koch,Ulrike May,Stefanie Kuhns,Hauke Drechsler,Nina Adam,Kirsten Hattermann,Stefan Wirtz,Stefan Rose-John, Scheller,

Interleukin 6 (IL6)-type cytokines are major regulators of inflammation and thereby contribute to the neuropathology and pathophysiology associated with inflammation of the central nervous system (CNS). Furthermore, astrocyte development which is a key process in the development of the CNS is also controlled by cytokines of the IL6-family. Interleukin 27 (IL27) is a recently identified member of this family and has been implicated in the inhibition of TH17 T-cell-responses. Here we show that IL27 and the HHV8 encoded viral IL6 (vIL6) induce C6 glioma cells to differentiate into an astrocyte-like state. Cytokine stimulation led to STAT-factor phosphorylation and consequently to protein expression of the astrocyte marker glial fibrillary acidic protein (GFAP). These data could be confirmed by GFAP-immunostaining of stimulated cells. Taken together, IL27 and vIL6 can be considered as new astrocyte-inducing cytokines of the brain.

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Publishing Authors By Initials

M Koch,U May,S Kuhns,H Drechsler,N Adam,K Hattermann,S Wirtz,S Rose-John,J Scheller,M Koch,U May,S Kuhns,H Drechsler,N Adam,K Hattermann,S Wirtz,S Rose-John,J Scheller,

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Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 364

Page Numbers: 483-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 17

MONTH: 10

YEAR: 2007

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.

AFFILIATION: Biochemisches Institut, Christian-Albrechts-Universität, Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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