Interleukin-1ra inhibits Fos expression and hyperalgesia in rats.

Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Research Abstract Details 

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Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Abstract Text:

Aihui Li,Lixing Lao,Yi Wang,Haiqing Zhang,Ke Ren,Brian M Berman,Ruixin Zhang,

It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-receptor antagonist (interleukin-1ra, 0.005 mg/rat) was given intrathecally twice, 24 h before complete Freund's adjuvant and immediately before complete Freund's adjuvant injection, to block interleukin-1beta action. Fos expression was measured 2 h after complete Freund's adjuvant injection. Paw withdrawal latency was used to assess hyperalgesia. The findings were that interleukin-1ra inhibited inflammation-induced Fos expression and hyperalgesia, which suggests that endogenous interleukin-1beta facilitates transmission of noxious messages at the spinal level by processes involving an enhanced Fos expression.

Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Publishing Authors By Initials

A Li,L Lao,Y Wang,H Zhang,K Ren,BM Berman,R Zhang,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroreport

VOLUME: 18

Page Numbers: 495-8

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 26

MONTH: Mar

YEAR: 2007

Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100935

Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: metabolism

Chemical & Substance for Abstract: Interleukin-1ra inhibits Fos expression and hyperalgesia in rats. Information

Substance Name: Freund's Adjuvant

Registry Number: 9007-81-2

Grant and Affiliation Information for Interleukin-1ra inhibits Fos expression and hyperalgesia in rats.

AFFILIATION: Center for Integrative Medicine, School of Medicine, Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland 21201, USA.

Country: England

AGENCY: United States NCCAM

GRANT: AT002605

ACRONYM: AT

MEDLINETA: Neuroreport

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