Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia.

Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Research Abstract Details 

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Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Abstract Text:

Theodore Lin,Weizhen Zhang,Yongyi Fan,Michael Mulholland,

Western blotting of culture media of myenteric glia stained positive for GFAP revealed increased secretion of matrix metalloproteinase-9 (MMP-9) in interleukin-1beta (IL-1beta) stimulated cells (10 ng/mL) versus control (142 +/- 19 versus 42 +/- 19, P < 0.05). Interleukin-6 (IL-6) stimulated cells also showed increased expression of MMP-9 (10 ng/mL) versus control (69 +/- 14 versus 4 +/- 2, P < 0.01). Control and cytokine-stimulated cells secreted MMP-2 constituitively. Gelatin zymography demonstrated that products were biologically active. Cytoplasmic staining for MMP-9 was detected in IL-1beta and IL-6-stimulated cells but was negligible in controls. Cultured myenteric glia are responsive to IL-1beta and IL-6 stimulation by secreting MMPs into the extracellular environment.

Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Publishing Authors By Initials

T Lin,W Zhang,Y Fan,M Mulholland,

For similar biological phenomena, cell phenomena, and immunity: immunity: neuroimmunomodulation research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: neuroimmunomodulation research

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Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of surgical research

VOLUME: 137

Page Numbers: 38-45

Journal Abbreviation: J. Surg. Res.

ISSN: 0022-4804

DAY: 15

MONTH: 11

YEAR: 2006

Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376340

Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Keywords Mesh Terms:

KEYWORDS: Neuroimmunomodulation

MESH TERMS: physiology

Chemical & Substance for Abstract: Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia. Information

Substance Name: Matrix Metalloproteinase 9

Registry Number: EC 3.4.24.35

Grant and Affiliation Information for Interleukin-1beta and interleukin-6 stimulate matrix metalloproteinase-9 secretion in cultured myenteric glia.

AFFILIATION: Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: T32 DK07698-09

ACRONYM: DK

MEDLINETA: J Surg Res

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