Interleukin-18 production and pulmonary function in COPD.

Interleukin-18 production and pulmonary function in COPD. Research Abstract Details 

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Interleukin-18 production and pulmonary function in COPD. Abstract Text:

H Imaoka,T Hoshino,S Takei,T Kinoshita,M Okamoto,T Kawayama,S Kato,H Iwasaki,K Watanabe,H Aizawa,

Interleukin (IL)-18 production and pulmonary function were evaluated in patients with chronic obstructive pulmonary disease (COPD) in order to determine the role of IL-18 in COPD. Immunohistochemical techniques were used to examine IL-18 production in the lungs of patients with very severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV, n = 16), smokers (n = 27) and nonsmokers (n = 23). Serum cytokine levels and pulmonary function were analysed in patients with GOLD stage I-IV COPD (n = 62), smokers (n = 34) and nonsmokers (n = 47). Persistent and severe small airway inflammation was observed in the lungs of ex-smokers with very severe COPD. IL-18 proteins were strongly expressed in alveolar macrophages, CD8+ T-cells, and both the bronchiolar and alveolar epithelia in the lungs of COPD patients. Serum levels of IL-18 in COPD patients and smokers were significantly higher than those in nonsmokers. Moreover, serum levels of IL-18 in patients with GOLD stage III and IV COPD were significantly higher than in smokers and nonsmokers. There was a significant negative correlation between serum IL-18 level and the predicted forced expiratory volume in one second in patients with COPD. In contrast, serum levels of IL-4, IL-13 and interferon-gamma were not significantly increased in any of the three groups. In conclusion, overproduction of interleukin-18 in the lungs may be involved in the pathogenesis of chronic obstructive pulmonary disease.

Interleukin-18 production and pulmonary function in COPD. Publishing Authors By Initials

H Imaoka,T Hoshino,S Takei,T Kinoshita,M Okamoto,T Kawayama,S Kato,H Iwasaki,K Watanabe,H Aizawa,

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Interleukin-18 production and pulmonary function in COPD. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The European respiratory journal : official journa

VOLUME: 31

Page Numbers: 287-97

Journal Abbreviation: Eur. Respir. J.

ISSN: 1399-3003

DAY: 7

MONTH: 11

YEAR: 2007

Interleukin-18 production and pulmonary function in COPD. Information

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LANGUAGE: eng

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AFFILIATION: Division of Respirology, Neurology and Rheumatology, Dept of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.

Country: Switzerland

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MEDLINETA: Eur Respir J

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