Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency.

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Research Abstract Details 

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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Abstract Text:

Eric P Zorrilla,Manuel Sanchez-Alavez,Shuei Sugama,Molly Brennan,Rosette Fernandez,Tamas Bartfai,Bruno Conti,Eric P Zorrilla,Manuel Sanchez-Alavez,Shuei Sugama,Molly Brennan,Rosette Fernandez,Tamas Bartfai,Bruno Conti,

Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show that administration of IL-18 suppresses appetite, feed efficiency, and weight regain in food-deprived male and female C57BL/6J mice. Intraperitoneal vs. intracerebroventricular routes of IL-18 administration had similar potency and did not promote formation of a conditioned taste aversion (malaise-like behavior). Mice partially (Il18(+/-)) or totally (Il18(-/-)) deficient in IL-18 were hyperphagic by young adulthood, with null mutants then becoming overweight by the fifth month of life. Adult Il18(-/-) mice gained 2- to 3-fold more weight than WT mice per unit energy consumed of low- or high-fat diet. Indirect calorimetry revealed reduced energy expenditure in female Il18(-/-) mice and increased respiratory exchange ratios [volume of carbon dioxide production (VCO(2))/volume of oxygen consumption (VO(2))] in mutants of both sexes. Hyperphagia continued in maturity, with overeating greatest during the mid- to late-dark cycle. Relative white fat-pad mass of Il18(-/-) mice was approximately 2- to 3-fold greater than that of WT, with gonadal, mesenteric, and inguinal depots growing most. The data suggest that endogenous IL-18 signaling modulates food intake, metabolism, and adiposity during adulthood and might be a central or peripheral pharmacological target for controlling energy homeostasis.

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Publishing Authors By Initials

EP Zorrilla,M Sanchez-Alavez,S Sugama,M Brennan,R Fernandez,T Bartfai,B Conti,EP Zorrilla,M Sanchez-Alavez,S Sugama,M Brennan,R Fernandez,T Bartfai,B Conti,

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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 11097-102

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 19

MONTH: 06

YEAR: 2007

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency.

AFFILIATION: Harold L. Dorris Neurological Research Institute, Committee on the Neurobiology of Addictive Disorders, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA. ezorrilla@scripps.edu

Country: United States

AGENCY: United States PHS

GRANT: P30N5057096

ACRONYM: NS

MEDLINETA: Proc Natl Acad Sci U S A

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