Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Research Abstract Details 

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Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Abstract Text:

Hui-Chen Hsu,PingAr Yang,John Wang,Qi Wu,Riley Myers,Jian Chen,John Yi,Tanja Guentert,Albert Tousson,Andrea L Stanus,Thuc-vy L Le,Robin G Lorenz,Hui Xu,Jay K Kolls,Robert H Carter,David D Chaplin,Robert W Williams,John D Mountz,

Interleukin 17 (IL-17) is a cytokine associated with inflammation, autoimmunity and defense against some bacteria. Here we show that IL-17 can promote autoimmune disease through a mechanism distinct from its proinflammatory effects. As compared with wild-type mice, autoimmune BXD2 mice express more IL-17 and show spontaneous development of germinal centers (GCs) before they increase production of pathogenic autoantibodies. We show that blocking IL-17 signaling disrupts CD4+ T cell and B cell interactions required for the formation of GCs and that mice lacking the IL-17 receptor have reduced GC B cell development and humoral responses. Production of IL-17 correlates with upregulated expression of the genes Rgs13 and Rgs16, which encode regulators of G-protein signaling, and results in suppression of the B cell chemotactic response to the chemokine CXCL12. These findings suggest a mechanism by which IL-17 drives autoimmune responses by promoting the formation of spontaneous GCs.

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Publishing Authors By Initials

HC Hsu,P Yang,J Wang,Q Wu,R Myers,J Chen,J Yi,T Guentert,A Tousson,AL Stanus,TV Le,RG Lorenz,H Xu,JK Kolls,RH Carter,DD Chaplin,RW Williams,JD Mountz,

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Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature immunology

VOLUME: 9

Page Numbers: 166-75

Journal Abbreviation: Nat. Immunol.

ISSN: 1529-2916

DAY: 23

MONTH: 12

YEAR: 2007

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Information

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LANGUAGE: eng

NlmUniqueID: 100941354

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Grant and Affiliation Information for Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.

AFFILIATION: Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. huichen.hsu@ccc.uab.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R24 DK64400

ACRONYM: DK

MEDLINETA: Nat Immunol

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