Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin.

Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Research Abstract Details 

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Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Abstract Text:

Huolin Tu,Peter L Rady,Terry Juelich,Stephen K Tyring,Nina Koldzic-Zivanovic,Eric M Smith,Thomas K Hughes,

AIM: The hypothalamic-pituitary-adrenal (HPA) axis is a mediator for interactions between the immune and neuroendocrine systems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) have been shown to activate the HPA axis. Recently, interleukin-10, an important anti-inflammatory cytokine in the immune system, has been shown to be expressed in the central nervous system and neuroendocrine system. Little is known, however, about IL-10's functions in the HPA axis. METHODS: The Affymetrix DNA microarray (mouse genome U74Av2 Probe Array) was conducted to determine the gene expression profile regulated by IL-10 in cells of HPA axis origin. RESULTS: In this study, we analyzed gene expression regulated by IL-10 in cells derived from the HPA axis. The results showed that quorums of genes are modulated by IL-10 in these neuroendocrine cells. CONCLUSIONS: These findings will provide a valuable repository to aid in understanding IL-10's functions in the HPA axis at the molecular level.

Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Publishing Authors By Initials

H Tu,PL Rady,T Juelich,SK Tyring,N Koldzic-Zivanovic,EM Smith,TK Hughes,

For similar endocrine system: endocrine glands: pituitary-adrenal system research abstracts see: endocrine system: endocrine glands: pituitary-adrenal system research

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Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular and molecular neurobiology

VOLUME: 27

Page Numbers: 161-70

Journal Abbreviation: Cell. Mol. Neurobiol.

ISSN: 0272-4340

DAY: 13

MONTH: 02

YEAR: 2007

Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8200709

Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Keywords Mesh Terms:

KEYWORDS: Pituitary-Adrenal System

MESH TERMS: immunology

Chemical & Substance for Abstract: Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin. Information

Substance Name: Interleukin-10

Registry Number: 130068-27-8

Grant and Affiliation Information for Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin.

AFFILIATION: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1019, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS041495-05

ACRONYM: NS

MEDLINETA: Cell Mol Neurobiol

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