Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma.

Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Research Abstract Details 

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Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Abstract Text:

Tamas Bartfai,Manuel Sanchez-Alavez,Siv Andell-Jonsson,Marianne Schultzberg,Annamaria Vezzani,Erik Danielsson,Bruno Conti,Tamas Bartfai,Manuel Sanchez-Alavez,Siv Andell-Jonsson,Marianne Schultzberg,Annamaria Vezzani,Erik Danielsson,Bruno Conti,

Proteins of the interleukin-1 (IL-1) system include the secreted agonist IL-1beta, and the receptor antagonist IL-1ra, both competing for binding to the IL-1 receptor (IL-1R). IL-1beta and IL-1ra are highly inducible under different forms of stress, such as excitatory neurotransmitter excess occurring during seizures, in infection and inflammation, and during neurotrauma. In each of these conditions induction of IL-1beta precedes that of IL-1ra, resulting in up to 10-20-fold elevation of IL-1beta concentrations. Consequently, IL-1beta induces the elevation of other proinflammatory molecules, including IL-6, IL-1R1, COX2, and iNOS, as well as of IL-1ra. Elevation of IL-1ra is of key importance for quenching the inflammatory response at the IL-1R1 as part of an autoregulatory loop. In seizures, IL-1ra is a strong anticonvulsant and in IL-1beta-dependent fever, a powerful antipyretic. In traumatic brain injury (TBI), the ability of patients to mount an IL-1ra response, as measured in the CSF, strongly correlated with the neurological outcome. Selective induction or pharmacological application of IL-1ra may be sparing neurons in seizures and neurotrauma.

Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Publishing Authors By Initials

T Bartfai,M Sanchez-Alavez,S Andell-Jonsson,M Schultzberg,A Vezzani,E Danielsson,B Conti,T Bartfai,M Sanchez-Alavez,S Andell-Jonsson,M Schultzberg,A Vezzani,E Danielsson,B Conti,

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Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1113

Page Numbers: 173-7

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 26

MONTH: 07

YEAR: 2007

Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Information

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LANGUAGE: eng

NlmUniqueID: 7506858

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Grant and Affiliation Information for Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma.

AFFILIATION: Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA. tbartfai@scripps.edu

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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