Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis.

Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Research Abstract Details 

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Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Abstract Text:

Lisa M Baye,Brian A Link,

During retinal development, neuroepithelial progenitor cells divide in either a symmetric proliferative mode, in which both daughter cells remain mitotic, or in a neurogenic mode, in which at least one daughter cell exits the cell cycle and differentiates as a neuron. Although the cellular mechanisms of neurogenesis remain unknown, heterogeneity in cell behaviors has been postulated to influence this cell fate. In this study, we analyze interkinetic nuclear migration, the apical-basal movement of nuclei in phase with the cell cycle, and the relationship of this cell behavior to neurogenesis. Using time-lapse imaging in zebrafish, we show that various parameters of interkinetic nuclear migration are significantly heterogeneous among retinal neuroepithelial cells. We provide direct evidence that neurogenic progenitors have greater basal nuclei migrations during the last cell cycle preceding a terminal mitosis. In addition, we show that atypical protein kinase C (aPKC)-mediated cell polarity is essential for the relationship between nuclear position and neurogenesis. Loss of aPKC also resulted in increased proliferative cell divisions and reduced retinal neurogenesis. Our data support a novel model for neurogenesis, in which interkinetic nuclear migration differentially positions nuclei in neuroepithelial cells and therefore influences selection of progenitors for cell cycle exit based on apical-basal polarized signals.

Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Publishing Authors By Initials

LM Baye,BA Link,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 10143-52

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 19

MONTH: Sep

YEAR: 2007

Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: physiology

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Grant and Affiliation Information for Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis.

AFFILIATION: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01EY01467

ACRONYM: EY

MEDLINETA: J Neurosci

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