Interictal lack of habituation of mismatch negativity in migraine.

Interictal lack of habituation of mismatch negativity in migraine. Research Abstract Details 

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Interictal lack of habituation of mismatch negativity in migraine. Abstract Text:

M de Tommaso,M Guido,G Libro,L Losito,O Difruscolo,M Sardaro,F M Puca,

The aim was to study mismatch negativity features and habituation during the interictal phase of migraine. In migraine patients, a strong negative correlation has been found between the initial amplitude of long latency auditory-evoked potentials and their amplitude increase during subsequent averaging. We studied 12 outpatients with a diagnosis of migraine without aura recorded in a headache-free interval and 10 gender- and age-matched healthy volunteers not suffering from any recurrent headache. The experiment consisted of two sequential blocks of 2000 stimulations, during which 1800 (90%) recordings for standard tones and 200 (10%) for target tones were selected for averaging. The latency of the N1 component was significantly increased in migraine patients in respect of controls in both the first and second repetitions; the MMN latency was increased in the second repetition. In the control group the MMN amplitude decreased on average by 3.2 +/- 1.4 microV in the second trial, whereas in migraine patients it showed a slight increase of 0.21 +/- 0.11 microV in the second repetition. The MMN latency relieved in the second trial was significantly correlated with the duration of illness in the migraine patients (Spearman correlation coefficient: 0.69; P < 0.05). The increases in N1 latency and MMN latency and amplitude, the latter correlated with duration of illness, seemed to be due to a reduced anticipatory effect of stimulus repetition in migraine patients. This suggests that such hypo-activity of automatic cortical processes, subtending the discrimination of acoustic stimuli, may be a basic abnormality in migraine, developing in the course of the disease.

Interictal lack of habituation of mismatch negativity in migraine. Publishing Authors By Initials

M de Tommaso,M Guido,G Libro,L Losito,O Difruscolo,M Sardaro,FM Puca,

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Interictal lack of habituation of mismatch negativity in migraine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cephalalgia : an international journal of headache

VOLUME: 24

Page Numbers: 663-8

Journal Abbreviation: Cephalalgia

ISSN: 0333-1024

DAY: 11

MONTH: Aug

YEAR: 2004

Interictal lack of habituation of mismatch negativity in migraine. Information

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LANGUAGE: eng

NlmUniqueID: 8200710

Interictal lack of habituation of mismatch negativity in migraine. Keywords Mesh Terms:

KEYWORDS: Reaction Time

MESH TERMS: physiology

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Grant and Affiliation Information for Interictal lack of habituation of mismatch negativity in migraine.

AFFILIATION: Department of Neurological and Psychiatric Sciences University of Bari, Italy. m.detommaso@neurol.uniba.it

Country: England

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MEDLINETA: Cephalalgia

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