Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus.

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Abstract Text:

Tim R Traynor,Jeannine A Majde,Stewart G Bohnet,James M Krueger,

The role of type I interferons (IFNs) in mediation of acute viral symptoms (fever, somnolence, anorexia, etc.) is unknown. To determine the role of type I IFN in selected symptom development, body temperature and sleep responses to a marginally lethal dose of X-31 influenza virus were examined in mice with a targeted mutation of the IFN receptor type I (IFN-RI knockouts) and compared to wild-type 129 SvEv control mice. Mice were monitored for 48 h to determine baseline temperature and sleep profiles prior to infection, and then for 9 days following infection. Hypothermic responses to virus were perceptible beginning at 64 h post-infection (PI) and were more marked in KO mice until 108 h, when hypothermia became more exaggerated in wild-type controls. Temperatures of wild-type mice continued to decline through day 9 while temperatures in IFN-RI KO mice stabilized. Time spent in non-rapid eye movement sleep (NREMS) increased in KO mice when hypothermia was marked and then returned to baseline levels, while NREMS continued to increase in wild-type mice through day 9. Other sleep parameters [time spent in rapid eye movement sleep (REMS), relative NREMS EEG slow wave activity, NREMS EEG power density] were all reduced in wild-type mice compared to KOs from days 3 to 8 while REMS low frequency EEG power density increased in wild-type relative to KOs. In conclusion, our results indicate that the presence of functional type I IFN slightly ameliorates disease symptoms early in the X-31 infection while exacerbating disease symptoms later in the infection.

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Publishing Authors By Initials

TR Traynor,JA Majde,SG Bohnet,JM Krueger,

For similar sleep: sleep stages research abstracts see: sleep: sleep stages research

PUBMED ID PMID:

MEDLINE DATE:

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain, behavior, and immunity

VOLUME: 21

Page Numbers: 311-22

Journal Abbreviation: Brain Behav. Immun.

ISSN: 0889-1591

DAY: 13

MONTH: 11

YEAR: 2006

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8800478

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Keywords Mesh Terms:

KEYWORDS: Sleep Stages

MESH TERMS: immunology

Chemical & Substance for Abstract: Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Information

Substance Name: Receptors, Interferon

Registry Number: 0

Grant and Affiliation Information for Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus.

AFFILIATION: Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS031453-14

ACRONYM: NS

MEDLINETA: Brain Behav Immun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus Related Publications

• A bifactor approach to modeling the structure of the psychopathy checklist-revised.
• Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses.
• Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR.
• Anterior canal benign paroxysmal positional vertigo: an underappreciated entity.
• Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1beta or tumor necrosis factor alpha.
• Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons.
• Detection of mouse-adapted human influenza virus in the olfactory bulbs of mice within hours after intranasal infection.
• Effects of Zernike wavefront aberrations on visual acuity measured using electromagnetic adaptive optics technology.
• Enterococcal colonization of infants in a neonatal intensive care unit: associated predictors, risk factors and seasonal patterns.
• Eruptive papules during efalizumab (anti-CD11a) therapy of psoriasis vulgaris: a case series.
• Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression.
• Influenza virus-induced glucocorticoid and hypothalamic and lung cytokine mRNA responses in dwarf lit/lit mice.
• Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus.
• Low-dose mitomycin C as a prophylaxis for corneal haze in myopic surface ablation.
• Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.
• MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.
• Novel insight into the agonistic mechanism of alefacept in vivo: differentially expressed genes may serve as biomarkers of response in psoriasis patients.
• Ocular surface research at alcon laboratories.
• Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research.
• Sleep in spontaneous dwarf rats.
• Surface wave elastometry of the cornea in porcine and human donor eyes.
• Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma.
• TNFalpha siRNA reduces brain TNF and EEG delta wave activity in rats.
• Taxonomy and inventory of the cytospecies and cytotypes of the Simulium damnosum complex (Diptera: Simuliidae) in relation to onchocerciasis.
• Techniques to study air-borne infections.
• The effect of sodium chloride on phage formation by staphylococci at elevated temperatures.
• The psychological benefits of vigorous exercise: a study of discordant MZ twin pairs.
• Unilateral cortical application of interleukin-1beta (IL1beta) induces asymmetry in fos, IL1beta and nerve growth factor immunoreactivity: implications for sleep regulation.
• [Not Available.]
• [Not Available.]