Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen.

Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen. Research Abstract Details 

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Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen. Abstract Text:

T Takaki,M Kobayashi,K Okubo,N Takahashi,Y Okamatsu,S Mochizuki,M Yamamoto,K Hasegawa,

OBJECTIVE: We investigated the possible roles of interferon-gamma (IFN-gamma) in modulation of extracellular and intracellular routes of collagen digestion by human fibroblasts. METHODS: Human gingival fibroblasts were treated with IFN-gamma, after which matrix metalloproteinase-1 (MMP-1) activation was determined. Following the IFN-gamma treatment, cells were further incubated with either activating antibody for beta1 integrin or actin monomer-sequestering agent latrunculin B before incubation with collagen-coated fluorescent beads. Thereafter, the binding and internalization of the beads were assessed. RESULTS: IFN-gamma had no significant effect on MMP-1 activation, however, it reduced the binding of collagen-coated beads in the minimum affinity range and, subsequently, internalization of the beads. The inhibitory effects of IFN-gamma were partially reversed by adding either the beta1 integrin activating antibody or latrunculin B. CONCLUSIONS: Although IFN-gamma does not appreciably moderate the extracellular route of collagen digestion by human fibroblasts, the reduced level of collagen phagocytosis by IFN-gamma in the cells may contribute to fibrosis in inflamed connective tissues. Further, IFN-gamma may decrease the binding of collagen and following phagocytosis in cells by inducing a subcortical actin assembly and reducing the ability of beta1 integrin to bind to collagen.

Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen. Publishing Authors By Initials

T Takaki,M Kobayashi,K Okubo,N Takahashi,Y Okamatsu,S Mochizuki,M Yamamoto,K Hasegawa,

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Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Inflammation research : official journal of the Eu

VOLUME: 55

Page Numbers: 534-42

Journal Abbreviation: Inflamm. Res.

ISSN: 1023-3830

DAY: 15

MONTH: Dec

YEAR: 2006

Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen. Information

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LANGUAGE: eng

NlmUniqueID: 9508160

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Grant and Affiliation Information for Interferon-gamma inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of beta1 integrin to bind to collagen.

AFFILIATION: Department of Periodontology, Showa University Dental School, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan.

Country: Switzerland

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MEDLINETA: Inflamm Res

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