Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells.

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Abstract Text:

Angela Papageorgiou,Colin P N Dinney,David J McConkey,Angela Papageorgiou,Colin P N Dinney,David J McConkey,

Apoptosis induced by interferon-alpha (IFNalpha) is associated with induction of TRAIL in a number of different cell types. Here we examined whether or not TRAIL was required for apoptosis in a model human bladder cancer cell line (UM-UC-12) and defined the molecular mechanisms involved in IFNalpha-induced TRAIL expression. Exposure to IFNalpha resulted in concentration-dependent induction of TRAIL and apoptosis. Inhibition of TRAIL or downstream components of the TRAIL cell death pathway (FADD, caspase-8) via siRNA-mediated knockdown attenuated IFNalpha-induced cell death, thereby implicating TRAIL in the response. IFNalpha induced rapid STAT-1 phosphorylation and DNA binding activity and subsequent accumulation of IRF-1. Transfection with siRNAs directed against STAT-1 or IRF-1 inhibited IFNalpha-induced TRAIL production and cell death, and chromatin immunprecipitation (ChIP) analyses demonstrated that IFNalpha induced direct, time-dependent binding of both transcription factors to the TRAIL promoter. Together, our results demonstrate that IFNalpha induces TRAIL expression via a STAT-1/IRF-1-dependent mechanism in human bladder cancer cells, and this induction of TRAIL plays an important role in IFNalpha-induced cell killing.

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Publishing Authors By Initials

A Papageorgiou,CP Dinney,DJ McConkey,A Papageorgiou,CP Dinney,DJ McConkey,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer biology & therapy

VOLUME: 6

Page Numbers: 872-9

Journal Abbreviation: Cancer Biol. Ther.

ISSN: 1538-4047

DAY: 1

MONTH: 03

YEAR: 2007

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101137842

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells.

AFFILIATION: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cancer Biol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells Related Publications

• 20S ways to apoptosis.
• A novel role for a familiar protein in apoptosis induced by proteasome inhibition.
• Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.
• Chuei-Fong-Tou-Geu-Wan in rheumatoid arthritis.
• Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells.
• Detection of polarized light in the vacuum UV.
• Drugs and rheumatoid arthritis.
• Effect on lipid profiles of switching from olanzapine to another second-generation antipsychotic agent in veterans with schizophrenia.
• Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.
• Frontline care in Irish intellectual disability services: The contribution of nurses and non-nurse care staff.
• If I had...Severe rheumatoid arthritis.
• Insulin oedema.
• Interferon-alpha Induces TRAIL Expression and Cell Death Via an IRF-1-Dependent Mechanism in Human Bladder Cancer Cells.
• Metabolic reconstruction and analysis for parasite genomes.
• Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.
• Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells.
• Osteoporosis and long-term corticosteroid therapy.
• Polarization analysis techniques in the VUV.
• Production and measurement of circular polarization in the VUV.
• Rheumatoid arthritis: C-reactive protein and erythrocyte sedimentation rate during initial treatment.
• Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes.
• Therapy-induced apoptosis in primary tumors.
• Variations in the polarization sensitivity of microchannel plates with photon incidence angle and wavelength in the VUV.