Interfering antiviral immunity: application, subversion, hope?

Interfering antiviral immunity: application, subversion, hope? Research Abstract Details 

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Interfering antiviral immunity: application, subversion, hope? Abstract Text:

N Manjunath,Priti Kumar,Sang Kyung Lee,Premlata Shankar,

RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vitro and in vivo in mouse and monkey models. These results have generated profound interest in the use of this technology as a potential treatment strategy for viral infections for which vaccines and drugs are unavailable or inadequate. In this review, we discuss the progress made within the past 2-3 years towards harnessing the potential of RNAi for clinical application in viral infections and the hurdles that have yet to be overcome.

Interfering antiviral immunity: application, subversion, hope? Publishing Authors By Initials

N Manjunath,P Kumar,SK Lee,P Shankar,

For similar virus diseases research abstracts see: virus diseases research

PUBMED ID PMID:

MEDLINE DATE:

Interfering antiviral immunity: application, subversion, hope? Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in immunology

VOLUME: 27

Page Numbers: 328-35

Journal Abbreviation: Trends Immunol.

ISSN: 1471-4906

DAY: 6

MONTH: 06

YEAR: 2006

Interfering antiviral immunity: application, subversion, hope? Information

Number of References: 73

LANGUAGE: eng

NlmUniqueID: 100966032

Interfering antiviral immunity: application, subversion, hope? Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Interfering antiviral immunity: application, subversion, hope? Information

Substance Name: RNA, Small Interfering

Registry Number: 0

Grant and Affiliation Information for Interfering antiviral immunity: application, subversion, hope?

AFFILIATION: The CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

Country: England

AGENCY: United States NIAID

GRANT: U19 AI 056900

ACRONYM: AI

MEDLINETA: Trends Immunol

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