Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Abstract Text:

Yukiyo Matsushita,Minoru Hasegawa,Takashi Matsushita,Manabu Fujimoto,Mayuka Horikawa,Tomoyuki Fujita,Ayako Kawasuji,Fumihide Ogawa,Douglas A Steeber,Thomas F Tedder,Kazuhiko Takehara,Shinichi Sato,

The tight-skin (TSK/+) mouse, a genetic model for systemic sclerosis, develops cutaneous fibrosis. Although a fibrillin 1 gene mutation and immunological abnormalities have been demonstrated, the roles of adhesion molecules have not been investigated. To directly assess roles of adhesion molecules in skin fibrosis, TSK/+ mice lacking L-selectin and/or ICAM-1 were generated. The deficiency of ICAM-1, but not L-selectin, significantly suppressed ( approximately 48%) the development of skin sclerosis in TSK/+ mice. Similarly, ICAM-1 antisense oligonucleotides inhibited skin fibrosis in TSK/+ mice. Although T cell infiltration was modest into the skin of TSK/+ mice, ICAM-1 deficiency down-regulated this migration, which is consistent with the established roles of endothelial ICAM-1 in leukocyte infiltration. In addition, altered phenotype or function of skin fibroblasts was remarkable and dependent on ICAM-1 expression in TSK/+ mice. ICAM-1 expression was augmented on TSK/+ dermal fibroblasts stimulated with IL-4. Although growth or collagen synthesis of TSK/+ fibroblasts cultured with IL-4 was up-regulated, it was suppressed by the loss or blocking of ICAM-1. Collagen expression was dependent on the strain of fibroblasts, but not on the strain of cocultured T cells. Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts.

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Publishing Authors By Initials

Y Matsushita,M Hasegawa,T Matsushita,M Fujimoto,M Horikawa,T Fujita,A Kawasuji,F Ogawa,DA Steeber,TF Tedder,K Takehara,S Sato,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE:

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 698-707

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2007

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: immunology

Chemical & Substance for Abstract: Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.

AFFILIATION: Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Country: United States

AGENCY: United States NCI

GRANT: CA96547

ACRONYM: CA

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice Related Publications

• Age related changes in the distribution of laryngeal glands in the human adult larynx.
• Anti-eosinophil peroxidase antibodies detected in patients with primary biliary cirrhosis.
• Assessment of bull fertility using a mucus penetration test and a human chorionic gonadotrophin stimulation test.
• Colonic mucosal lesions associated with long-term administration of non-steroidal anti-inflammatory drugs.
• Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
• Differences in acetazolamide vasoreactivity in patients with acute and chronic occlusion of the internal carotid artery.
• Effect of low-molecular-weight heparin on the commitment of bone marrow cells to liver sinusoidal endothelial cells in CCl(4)-induced liver injury.
• Effects of gonadotropin releasing hormone and prostaglandin F(2)alpha on the reproductive performance in postpartum cows.
• Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic KK-A(y) mice.
• Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma.
• Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients.
• Expression of mucin antigens in human cancers and its relationship with malignancy potential.
• Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor.
• Hepatic steatosis is a predictor of poor response to interferon alpha-2b and ribavirin combination therapy in Japanese patients with chronic hepatitis C.
• Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors.
• Infective Endocarditis Associated with Sjogren's Syndrome.
• Isokinetic external rotation strength of shoulder : correlation with age and muscle size.
• MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas.
• MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients.
• Mechanism by which Bombyx mori hemocytes recognize microorganisms: direct and indirect recognition systems for PAMPs.
• Modeling of daily operation in proton radiotherapy by Monte Carlo method.
• Mucin antigen expression in gastric carcinomas of young and old adults.
• Prostaglandin E(2) levels in uterine tissues and its relationship with uterine and luteal progesterone during the estrous cycle in dairy cows.
• Reconstruction of scalp and cranium defect utilizing latissimus dorsi musculocutaneous and serratus anterior muscle free flaps with interpositional anastomosis of T-shaped flap artery: case report.
• Second messenger systems mediating sex pheromone and amino Acid sensitivity in goldfish olfactory receptor neurons.
• Study on the appearance of the cavity in the corpus luteum of cows by using ultrasonic scanning.
• The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms.
• The role of leptin in progression of non-alcoholic fatty liver disease.
• Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats.
• [Development and operation of cultured cell experiment with TR-IA sounding rocket]