Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children.

Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Research Abstract Details 

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Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Abstract Text:

Tanya E Froehlich,Bruce P Lanphear,Kim N Dietrich,Deborah A Cory-Slechta,Ning Wang,Robert S Kahn,

BACKGROUND: Prior studies have examined independent effects of a dopamine receptor D4 polymorphism (DRD4-7) and lead exposure on executive functions but not their interaction or the role of sex as a modifier of their effects. METHODS: Multivariable analyses were used to examine effects of DRD4-7 genotype, 60-month blood lead level, and sex on spatial working memory, rule learning and reversal, spatial span, and planning for 174 children. RESULTS: DRD4-7 was associated with poorer spatial working memory, and increasing blood lead levels were associated with impaired rule learning and reversal, spatial span, and planning. Adverse effects of lead on planning and rule learning and reversal were seen primarily for boys. In addition, the effect of lead on rule learning and reversal was evident predominately for those lacking DRD4-7. CONCLUSIONS: We observed independent effects of DRD4-7 and lead on various executive functions and modifications of lead effects by DRD4 genotype and sex.

Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Publishing Authors By Initials

TE Froehlich,BP Lanphear,KN Dietrich,DA Cory-Slechta,N Wang,RS Kahn,

For similar investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research

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Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 62

Page Numbers: 243-9

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 17

MONTH: 01

YEAR: 2007

Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 213264

Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Keywords Mesh Terms:

KEYWORDS: Statistics, Nonparametric

MESH TERMS: physiology

Chemical & Substance for Abstract: Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Information

Substance Name: Lead

Registry Number: 7439-92-1

Grant and Affiliation Information for Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children.

AFFILIATION: Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. tanya.froehlich@cchmc.org

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES08388

ACRONYM: ES

MEDLINETA: Biol Psychiatry

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