Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy.

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Abstract Text:

W E Serafin,S H Dement,S Brandon,E J Hill,C R Park,J H Park,

Our prior work demonstrated that penicillamine treatment of dystrophic chickens delayed the onset of symptoms, partially alleviated contractures, improved muscle function, and lowered serum creatine kinase. Penicillamine, a sulfhydryl compound with reducing properties, also prevented inactivation of glycolytic enzymes by protecting thiol groups. The present study shows that vitamin E enhances the therapeutic effects of penicillamine. Interaction of these two reductants is dose related. With vitamin E as adjunct therapy, the dosage level of penicillamine could be lowered by 50%, thereby minimizing side effects. The therapeutic rationale for two antioxidants is that penicillamine may act primarily in the cytoplasm to prevent oxidative damage, whereas the more hydrophobic vitamin E may protect membrane bilayers. Additionally, penicillamine may prevent collagen cross-linking and, deposition of insoluble collagen in muscle and thus decrease contracture formation. General applications of combined penicillamine and vitamin E therapy are discussed regarding prevention of free radical and oxidative damage in Duchenne dystrophy and a wide range of human diseases.

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Publishing Authors By Initials

WE Serafin,SH Dement,S Brandon,EJ Hill,CR Park,JH Park,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

PUBMED ID PMID:

MEDLINE DATE:

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Muscle & nerve

VOLUME: 10

Page Numbers: 685-97

Journal Abbreviation: Muscle Nerve

ISSN: 0148-639X

DAY: 19

MONTH: Oct

YEAR: 1987

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803146

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy. Information

Substance Name: Creatine Kinase

Registry Number: EC 2.7.3.2

Grant and Affiliation Information for Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy.

AFFILIATION: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232.

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: GM-07884

ACRONYM: GM

MEDLINETA: Muscle Nerve

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy Related Publications

• Abc amino acids: design, synthesis, and properties of new photoelastic amino acids.
• Age-related stereotypes: a comparison of American and Chinese cultures.
• Categorical organization in free recall across culture and age.
• Duration of thawing on post thaw acrosome morphology and motility of boar spermatozoa frozen in 5-ml maxi-straws.
• Epstein-Barr virus infected natural killer cell lymphoma in a patient with hypersensitivity to mosquito bite.
• Expression of mucin genes in chronic ethmoiditis.
• Inhibition of IL-8 production by green tea polyphenols in human nasal fibroblasts and a549 epithelial cells.
• Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy.
• Molecular cloning and characterization of a novel mouse betaPix isoform.
• Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.
• Post-traumatic pseudomeningocele presenting as a cyst of external auditory canal: report of a case.
• Selection of neural differentiation-specific genes by comparing profiles of random differentiation.
• Source memory, aging and culture.
• Stimulation of melanogenesis by scoparone in B16 melanoma cells.
• Stunning and I-123 use for diagnostic whole body scanning.
• [A case of adenosquamous carcinoma of the papilla of Vater]
• [A case of colon cancer associated with Crohn's disease]
• [A case of gastric variceal bleeding due to pancreatic cancer]
• [A comparative study on family perception between abused children and normal children by Kinetic Family Drawing]
• [A comparison of interventions recorded in nursing notes between acute and subacute stage after a cerebrovascular accident]
• [A study on health perception and health promoting behavior in chronic back pain patients]
• [Comparison of influential variables for smoking temptation between adolescent and adult smokers]
• [Detection of liver metastases and recurrence using PET-CT scan in a patient with rectal cancer]
• [Effects of on education program for nurses on the use of restraints]
• [Gossypiboma (Textiloma) due to retained surgical gauze]
• [Primary biliary cirrhosis]
• [Process of seeking positive life of patients with Parkinson's disease]
• [Research trend of complementary and alternative medicine]
• [The effects of a recovery education program on rehabilitation motivation, symptoms, and function for schizophrenic patients]
• [The effects of a rehabilitation program on physical health, physiological indicator and quality of life in breast cancer mastectomy patients]