Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers.

Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers. Research Abstract Details 

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Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers. Abstract Text:

Fumikazu Suto,Miu Tsuboi,Haruyuki Kamiya,Hidenobu Mizuno,Yuji Kiyama,Shoji Komai,Masayuki Shimizu,Makoto Sanbo,Takeshi Yagi,Yasushi Hiromi,Alain ,Kevin J Mitchell,Toshiya Manabe,Hajime Fujisawa,

Hippocampal mossy fibers project preferentially to the stratum lucidum, the proximal-most lamina of the suprapyramidal region of CA3. The molecular mechanisms that govern this lamina-restricted projection are still unknown. We examined the projection pattern of mossy fibers in mutant mice for semaphorin receptors plexin-A2 and plexin-A4, and their ligand, the transmembrane semaphorin Sema6A. We found that plexin-A2 deficiency causes a shift of mossy fibers from the suprapyramidal region to the infra- and intrapyramidal regions, while plexin-A4 deficiency induces inappropriate spreading of mossy fibers within CA3. We also report that the plexin-A2 loss-of-function phenotype is genetically suppressed by Sema6A loss of function. Based on these results, we propose a model for the lamina-restricted projection of mossy fibers: the expression of plexin-A4 on mossy fibers prevents them from entering the Sema6A-expressing suprapyramidal region of CA3 and restricts them to the proximal-most part, where Sema6A repulsive activity is attenuated by plexin-A2.

Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers. Publishing Authors By Initials

F Suto,M Tsuboi,H Kamiya,H Mizuno,Y Kiyama,S Komai,M Shimizu,M Sanbo,T Yagi,Y Hiromi,A ,KJ Mitchell,T Manabe,H Fujisawa,

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Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuron

VOLUME: 53

Page Numbers: 535-47

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 15

MONTH: Feb

YEAR: 2007

Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

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AFFILIATION: Division of Developmental Genetics, National Institute of Genetics, Mishima 411-8540, Japan; CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.

Country: United States

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MEDLINETA: Neuron

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