Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer.

Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer. Research Abstract Details 

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Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer. Abstract Text:

Matthieu Perreau,Marie-Christine ,Christian Drouet,Eric J Kremer,Matthieu Perreau,Marie-Christine ,Christian Drouet,Eric J Kremer,Matthieu Perreau,Marie-Christine ,Christian Drouet,Eric J Kremer,

By the time we are adolescents most of us have been in contact with several of the >50 human adenovirus (HAd) serotypes. These common subclinical infections lead to an efficient anti-adenovirus cross-reacting adaptive immunity. During gene therapy, the ubiquitous anti-adenovirus humoral response and complement activation will modify and dictate vector biodistribution, as well as the response to the virion and transgene(s). In this study, we assayed the interactions of a xenogenic adenovirus derived from canine serotype 2 (CAV-2) with naturally occurring human antibodies (Abs) and the complement system. In our cohort, we found class G immunoglobulins (Igs) that recognized the intact CAV-2 virion and the external virion proteins. However, the majority of donors had low or no neutralizing Abs, class A, or class M Igs. Purified anti-HAd serotype 5 Abs also recognized CAV-2 virion proteins. In addition, in spite of the presence of anti-CAV-2 IgGs, CAV-2 poorly activated the classical and alternative complement cascades. This atypical response was due to a block upstream of the component 3 (C3) convertase and interplay between the component 1 (C1) inhibitor, the C1q-C1r2-C1s2 complex and CAV-2. Our data demonstrate that some xenogenic adenovirus vectors, like CAV-2, could lead to notably different outcomes following systemic delivery.Molecular Therapy (2007) 15 11, 1998-2007. doi:10.1038/sj.mt.6300289.

Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer. Publishing Authors By Initials

M Perreau,MC ,C Drouet,EJ Kremer,M Perreau,MC ,C Drouet,EJ Kremer,M Perreau,MC ,C Drouet,EJ Kremer,

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Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 15

Page Numbers: 1998-2007

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 21

MONTH: 08

YEAR: 2007

Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Interactions between human plasma components and a xenogenic adenovirus vector: reduced immunogenicity during gene transfer.

AFFILIATION: [1] 1Institut de Génétique Moléculaire de Montpellier, Montpellier, France [2] 2CNRS-Universities of Montpellier I and II, Montpellier, France.

Country: United States

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