Interaction of TACC proteins with the FHL family: implications for ERK signaling.

Interaction of TACC proteins with the FHL family: implications for ERK signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Interaction of TACC proteins with the FHL family: implications for ERK signaling. Abstract Text:

The Transforming acidic coiled coil (TACC) proteins play a conserved role in normal development and tumorigenesis through interactions with multiple complexes involved in transcription, translation, and centrosomal dynamics. However, despite significant work on the function of TACC3 in the control of centrosomal mechanics, relatively little functional data is known about the family's founding member, TACC1. From a continued analysis of clones isolated by an unbiased yeast two-hybrid assay, we now show direct physical interactions between the TACC1 and the FHL (Four and a Half LIM-only) family of proteins. The authenticity of these interactions was validated both in vitro and in cellular systems. The FHLs exhibit diverse biological roles such as the regulation of the actin cytoskeleton and are promiscuous coregulators for several transcription factors. The interaction of the endogenous TACC-FHL proteins is primarily localized to the nucleus. However, similar to FHL2, overexpression of TACC1A in HEK293 is able to sequester serum activated ERK to the cytoplasm. This has the effect of reducing the serum induced transcriptional response of the c-fos and c-jun genes. The observation that TACCs can interact with the FHLs and alter their serum induced activities raises the possibility that the TACCs participate in crosstalk between cell signaling pathways important for cancer development and tumor progression. The transforming acidic coiled coil genes are known to be important prognostic indicators for breast, ovarian and lung cancer. In this manuscript, we identify a novel interaction between the TACCs and the FHL protein family. This interaction has an affect on ERK and may in part explain the variable associations and changes in subcellular locations of each family with specific subtypes of malignancy.

Interaction of TACC proteins with the FHL family: implications for ERK signaling. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Interaction of TACC proteins with the FHL family: implications for ERK signaling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cell communication and signaling

VOLUME: 1

Page Numbers: 5-15

Journal Abbreviation:

ISSN: 1873-9601

DAY: 28

MONTH: 03

YEAR: 2007

Interaction of TACC proteins with the FHL family: implications for ERK signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101308338

Interaction of TACC proteins with the FHL family: implications for ERK signaling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Interaction of TACC proteins with the FHL family: implications for ERK signaling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Interaction of TACC proteins with the FHL family: implications for ERK signaling.

AFFILIATION: Department of Physical Sciences, Arkansas Tech University, 1701 N Boulder Ave, Russellville, AR, 72802, USA, blauffart@atu.edu.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cell Commun Signal

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Interaction of TACC proteins with the FHL family: implications for ERK signaling Related Publications

• Adult preventive medicine: the fourth phase in the evolution of medicine.
• Climate, phylogeny and the ecological distribution of C4 grasses.
• Convulsions in infancy and childhood. 1907.
• Dose rate effect on LD50-30 in mice exposed to cobalt-60 gamma irradiation. SAM-TR-68-97.
• Dose-rate studies with sheep and swine. NRDL-TR-68-96.
• ENDOCARDIAL THICKENING ASSOCIATED WITH DISEASED VALVES.
• Evaluation of the effect of implanted depleted uranium (DU) on adult rat behavior and toxicological endpoints.
• Further observations on the need for a National Scientific R & D Budget.
• Interaction of TACC proteins with the FHL family: implications for ERK signaling.
• Metastatic carcinoma at the site of injection of iron-dextran complex.
• Nephrotic syndrome with oat-cell carcinoma.
• Now you see it, now you don't: Repetition blindness for nonwords.
• Optics and philosophy.
• Solubility of ethylenediamine D-tartrate in water.
• Temporal and spatial expression of TACC1 in the mouse and human.
• The birth of a profession: osteopathic medicine.
• The cybernetic theory of aging.
• The effect of massive doses of 32-MeV protons and Co-60 gamma radiation on serum enzyme levels of whole-body irradiated primates. SAM-TR-65-22.
• The significance of anisocoria.
• Tinea barbae.
• To be or not to be--alive or dead?