Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects.

Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects. Research Abstract Details 

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Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects. Abstract Text:

L E Eriksson,J Westman,

Adsorptions of amphiphilic drugs (propranolol, alprenolol, metoprolol and tetracaine) to phosphalidylcholine vesicles in media of different pH and NaCl concentrations have been studied. A positively charged spin label amphiphile, N,N-di-methyl-N-nonyl-N-tempoylammoniumbromide, was used to follow the variation in the surface potential by ESR. Competition experiments between the probe molecule and the drugs were carried out. A spin-labeled analogue of propranolol was also employed. We have analysed the results in terms of the theory for the diffuse double layer (Gouy-Chapman) and treated various equilibrium models. A weak, specific adsorption of chloride ions was introduced. For the charged forms of the drugs simulations of the experiments by numerical solution of the system of equations in a satisfactory way furnished intrinsic binding constants, independent of surface potential effects. The common electrostatic surface potential is mainly ruling the competition, and not the number of surface vacancies.

Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects. Publishing Authors By Initials

LE Eriksson,J Westman,

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Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biophysical chemistry

VOLUME: 13

Page Numbers: 253-64

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ISSN: 0301-4622

DAY: 26

MONTH: Jun

YEAR: 1981

Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Interaction of some charged amphiphilic drugs with phosphatidylcholine vesicles A spin label study of surface potential effects.

AFFILIATION: Department of Biophysics, University of Stockholm, Arrhenhis Laboratory, S-106 91 Stockholm, Sweden.

Country: Netherlands

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MEDLINETA: Biophys Chem

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