Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity.

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Research Abstract Details 

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Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Abstract Text:

N Sitaram,R Nagaraj,

Species right across the evolutionary scale from insects to mammals use peptides as part of their host-defense system to counter microbial infection. The primary structures of a large number of these host-defense peptides have been determined. While there is no primary structure homology, the peptides are characterized by a preponderance of cationic and hydrophobic amino acids. The secondary structures of many of the host-defense peptides have been determined by a variety of techniques. The acyclic peptides tend to adopt helical conformation, especially in media of low dielectric constant, whereas peptides with more than one disulfide bridge adopt beta-structures. Detailed investigations have indicated that a majority of these host-defense peptides exert their action by permeabilizing microbial membranes. In this review, we discuss structural and charge requirements for the interaction of endogenous antimicrobial peptides and short peptides that have been derived from them, with membranes.

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Publishing Authors By Initials

N Sitaram,R Nagaraj,

For similar sulfhydryl compounds research abstracts see: sulfhydryl compounds research

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Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Journal Published:

PUBLICATION TYPE: Review

Journal: Biochimica et biophysica acta

VOLUME: 1462

Page Numbers: 29-54

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 15

MONTH: Dec

YEAR: 1999

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Information

Number of References: 219

LANGUAGE: eng

NlmUniqueID: 217513

Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Keywords Mesh Terms:

KEYWORDS: Sulfhydryl Compounds

MESH TERMS: chemistry

Chemical & Substance for Abstract: Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity. Information

Substance Name: pardaxin

Registry Number: 67995-63-5

Grant and Affiliation Information for Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activity.

AFFILIATION: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India.

Country: NETHERLANDS

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MEDLINETA: Biochim Biophys Acta

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