Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF).

Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Research Abstract Details 

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Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Abstract Text:

Jorik Arts,Arjan de Groot, Ball,Eric Durand,Mohammed El Khattabi,Alain Filloux,Jan Tommassen,Margot Koster,

Pseudomonas aeruginosa is an opportunistic pathogen, which secretes a wide variety of enzymes and toxins into the extracellular medium. Most exoproteins are exported by the type II secretion machinery, the Xcp system, which encompasses 12 different proteins. One of the core components of the Xcp system is the inner-membrane protein XcpS (GspF), homologues of which can be identified in type II secretion machineries as well as in type IV piliation systems. In this study, XcpS was shown to be stabilized by co-expression of the XcpR (GspE) and XcpY (GspL) components of the machinery, demonstrating an interaction between these three proteins. By replacing segments of P. aeruginosa XcpS with the corresponding parts of its Pseudomonas putida counterpart, XcpS domains were identified that are important for species-specific functioning and thus represent putative interaction domains. The cytoplasmic loop of XcpS was found to be involved in the stabilization by XcpR and XcpY.

Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Publishing Authors By Initials

J Arts,A de Groot,G Ball,E Durand,M El Khattabi,A Filloux,J Tommassen,M Koster,

For similar genetic processes: recombination, genetic research abstracts see: genetic processes: recombination, genetic research

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Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 1582-92

Journal Abbreviation:

ISSN: 1350-0872

DAY: 28

MONTH: May

YEAR: 2007

Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Information

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LANGUAGE: eng

NlmUniqueID: 9430468

Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Keywords Mesh Terms:

KEYWORDS: Recombination, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF). Information

Substance Name: xcpY protein, Pseudomonas aeruginosa

Registry Number: 137630-08-1

Grant and Affiliation Information for Interaction domains in the Pseudomonas aeruginosa type II secretory apparatus component XcpS (GspF).

AFFILIATION: Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, the Netherlands.

Country: England

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MEDLINETA: Microbiology

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