Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.

Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. Research Abstract Details 

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Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. Abstract Text:

Xinyan Zhao,Bo Zheng,Yanfang Huang,Dan Yang,Shoshana Katzman,Chawnshang Chang,Deborah Fowell,Wei-Ping Zeng,Xinyan Zhao,Bo Zheng,Yanfang Huang,Dan Yang,Shoshana Katzman,Chawnshang Chang,Deborah Fowell,Wei-ping Zeng,

Th2 cytokine expression is dependent on the transcription factor GATA-3. However, the molecular interactions of GATA-3 leading to Th2 cytokine gene activation have not been well characterized. Here, we reported a number of GATA-3 associated proteins in Th2 cells, and one of such proteins Pias1 functioned as a positive transcriptional coregulator for GATA-3. When overexpressed in Th2 cells, Pias1 enhanced the expression of IL-13, and to lesser degrees, IL-4 and -5. Conversely, Pias1 siRNA down-regulated the Th2 cytokine expression. In Leishmania major infection, manipulating Pias1 expression in parasite-reactive CD4 T cells altered severity of disease caused by Th2 responses. Mechanistically, Pias1 markedly potentiated GATA-3-mediated activation of the IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter. In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter. Thus, both promoter activation and additional mechanisms are responsible for regulation by Pias1.

Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. Publishing Authors By Initials

X Zhao,B Zheng,Y Huang,D Yang,S Katzman,C Chang,D Fowell,WP Zeng,X Zhao,B Zheng,Y Huang,D Yang,S Katzman,C Chang,D Fowell,WP Zeng,

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Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 8297-304

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Dec

YEAR: 2007

Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses.

AFFILIATION: David H. Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01-AI47263

ACRONYM: AI

MEDLINETA: J Immunol

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