Inter-rater agreement of assessed prenatal maternal occupational exposures to lead.

Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Research Abstract Details 

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Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Abstract Text:

Adolfo Correa,Yuan-I Min,Patricia Ann Stewart,Peter S J Lees,Patrick Breysse,Mustafa Dosemeci,Leila W Jackson,

BACKGROUND: Industrial hygienists' assessments of prenatal occupational exposures based on parental job histories is a promising approach for population-based case-control studies of birth defects and other perinatal outcomes. However, evaluations of inter-rater agreement of such assessments have been limited. METHODS: We examined inter-rater agreement of occupational lead exposure assessments of maternal job reports by industrial hygienists in a population-based case-control study of parental occupational lead exposure and low birth weight. A total of 178 jobs with potential exposure to lead during the 6 months before pregnancy to the end of pregnancy were examined. Three industrial hygienists evaluated these jobs independently for exposure to lead including probability of exposure, type of exposure, route of entry, exposure frequency, duration, and intensity. Inter-rater agreement of these assessments beyond chance was evaluated using the kappa statistic (kappa). RESULTS: In general, inter-rater agreement was greater for assessment of direct exposures than assessment of indirect exposures. However, inter-rater agreement varied with the lead exposure metric under consideration, being: 1) fair to good for type of direct exposure (i.e., inorganic or organic), respiratory exposure and frequency of exposure to direct inorganic lead, hours per day of direct (i.e., inorganic or organic), and intensity of direct inorganic exposure; 2) poor for probability and type of indirect exposure (inorganic or organic); and 3) indeterminate for frequency of direct organic exposure, frequency of indirect exposures (organic or inorganic), and intensity of direct exposures (organic or inorganic). CONCLUSION: Retrospective assessment of maternal prenatal exposures to lead by industrial hygienists can provide some reliable metrics of exposure for studies of perinatal outcomes. Reliability studies of such exposure assessments may be useful for: quantifying the reliability of derived exposure metrics; identifying exposure metrics for exposure-outcome analyses; and determining the reliability of prenatal occupational exposures to other agents of interest.

Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Publishing Authors By Initials

A Correa,YI Min,PA Stewart,PS Lees,P Breysse,M Dosemeci,LW Jackson,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

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Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Birth defects research. Part A, Clinical and molec

VOLUME: 76

Page Numbers: 811-24

Journal Abbreviation: Birth Defects Res. Part A Clin

ISSN: 1542-0752

DAY: 3

MONTH: Nov

YEAR: 2006

Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101155107

Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Inter-rater agreement of assessed prenatal maternal occupational exposures to lead. Information

Substance Name: Lead

Registry Number: 7439-92-1

Grant and Affiliation Information for Inter-rater agreement of assessed prenatal maternal occupational exposures to lead.

AFFILIATION: Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA. acorrea@cdc.gov

Country: United States

AGENCY: United States NIEHS

GRANT: R29 ES06218

ACRONYM: ES

MEDLINETA: Birth Defects Res A Clin Mol T

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