Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation.

Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. Research Abstract Details 

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Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. Abstract Text:

Background: Recently we reported that signal transmission of interferon is more suppressed by tacrolimus (Tac) than cycrosporine (CyA). Therefore, although CyA might be beneficial immunosuppressive drug after liver transplantation (LT) on interferon therapy against hepatitis C virus, it is hesitated because of the risk for provocation of rejection. Herein initial outcome of our strategy, i.e. intentional conversion from Tac to CyA during preemptive interferon therapy after living donor LT (LDLT) was reported.
Material/Methods: Of 62 patients who had undergone LDLT in Nagasaki University Hospital between 1997 and November 2006, 16 patients showed indications for hepatitis C-related liver cirrhosis. The median follow-up period was 15 months. Tac was used for all patients as induction therapy combined with steroids tapering.
Results: In 11 out of 16 cases (68.8%), preemptive Pegylated (Peg)-IFN-alpha 2b+Ribavirin therapy was initiated. When Peg-IFN-alpha 2b+Ribavirin therapy was commenced, Tac-to- CyA conversion was done. The median period of conversion from Tac to CyA was 1.5 month after LDLT. After the conversion, ACR occurred in one case. Out of 11 patients, 3 patients (21.4%) showed early viral response (VR) at 3 months, 2 showed end-treatment response at 48 weeks (14.3%) and 3 showed sustained VR (21.4%).
Conclusions: Intentional conversion from Tac to CyA can be safely performed without increasing the risk of ACR.

Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. Publishing Authors By Initials

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Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of transplantation : quarterly of the Polis

VOLUME: 12

Page Numbers: 11-5

Journal Abbreviation: Ann. Transplant.

ISSN: 1425-9524

DAY: 17

MONTH: 03

YEAR: 2007

Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation.

AFFILIATION: Departments of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Country: Poland

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MEDLINETA: Ann Transplant

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