Integrity of cell-free plasma DNA in patients with lung cancer and nonmalignant lung disease.

Integrity of cell-free plasma DNA in patients with lung cancer and nonmalignant lung disease. Research Abstract Details 

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Integrity of cell-free plasma DNA in patients with lung cancer and nonmalignant lung disease. Abstract Text:

In several papers an increased quantity of cell-free plasma DNA as well as the presence of long DNA fragments in cell-free plasma and serum has been described. We isolated cell-free DNA from plasma, serum, and bronchial lavage supernatants from 33 lung cancer patients and 27 patients with a benign lung disease. The DNA was amplified by real-time PCR, and the quantity as well as the DNA integrity was determined. We did not find significant differences between the patient populations. Our results led us to conclude that this method is not useful in a diagnostic setting and is not able to differentiate between lung cancer patients and patients with a benign lung disease.

Integrity of cell-free plasma DNA in patients with lung cancer and nonmalignant lung disease. Publishing Authors By Initials

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Integrity of cell-free plasma DNA in patients with lung cancer and nonmalignant lung disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1137

Page Numbers: 207-13

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 1749-6632

DAY: 7

MONTH: Aug

YEAR: 2008

Integrity of cell-free plasma DNA in patients with lung cancer and nonmalignant lung disease. Information

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LANGUAGE: eng

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AFFILIATION: Medizinische Klinik m.S. Infektiologie und Pneumologie, Pneumologie, Charité-Universitätsmedizin, Berlin, Germany.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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