Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn.

Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Research Abstract Details 

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Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Abstract Text:

Claire C Bastie,Haihong Zong,Jun Xu,Bhavin Busa,Stefan Judex,Irwin J Kurland,Jeffrey E Pessin,Claire C Bastie,Haihong Zong,Jun Xu,Bhavin Busa,Stefan Judex,Irwin J Kurland,Jeffrey E Pessin,

Mice null for Fyn (a member of the Src family of nonreceptor tyrosine kinases) display a reduced percentage of adipose mass associated with decreased adipocyte cell size. In parallel, there is a substantial reduction in fasting plasma glucose, insulin, triglycerides, and free fatty acids concomitant with decreased intrahepatocellular and intramyocellular lipid accumulation. Importantly, the Fyn null mice exhibit improved glucose tolerance resulting from increased peripheral tissue (adipose and skeletal muscle) insulin sensitivity with a very small effect in the liver. Moreover, whole-body, adipose, and skeletal muscle fatty acid uptake and oxidation are increased along with AMP kinase activation and acetyl-CoA carboxylase inhibition. Together, these data demonstrate crosstalk between Src-family kinase activity and fatty acid oxidation and show that the loss of Fyn markedly improves peripheral tissue insulin sensitivity by relieving a selective negative modulation of AMP kinase activity in adipose tissue and skeletal muscle.

Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Publishing Authors By Initials

CC Bastie,H Zong,J Xu,B Busa,S Judex,IJ Kurland,JE Pessin,CC Bastie,H Zong,J Xu,B Busa,S Judex,IJ Kurland,JE Pessin,

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Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell metabolism

VOLUME: 5

Page Numbers: 371-81

Journal Abbreviation: Cell Metab.

ISSN: 1550-4131

DAY: 9

MONTH: May

YEAR: 2007

Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn.

AFFILIATION: Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK58132

ACRONYM: DK

MEDLINETA: Cell Metab

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