Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Abstract Text:

V Perez-De La Cruz,A Santamaria,V Perez-De La Cruz,A Santamaria,V Perez-De La Cruz,A Santamaria,V Perez-De La Cruz,A Santamaria,

Huntington's disease (HD) is a demential, neurodegenerative inheritable disease affecting middle-aged patients. HD is characterized by uncontrolled choreiform movements, psychiatric symptoms and cognitive decline. Histopathological changes in HD brains reveal a considerable damage to basal ganglia, particularly affecting middle-sized spiny neurons from the caudate-putamen region. Neurochemical changes are specifically oriented to deplete GABAergic and cholinergic systems, while molecular alterations include an increased expression of CAG trinucleotide at exon 1 from the huntingtin (htt) gene, as well as aggregation of mutant htt. Although several hypotheses regarding the mechanisms by which neurotoxicity is triggered in HD brains have been suggested on the basis of experimental evidence, so far it remains not clear which of them are predominant or whether they are complementary. Recent experimental evidence through transgenic mice models reveal an interesting interaction between expanded CAG triplets, mutant htt, and the increase in toxic metabolites from the kynurenine pathway. Further evidence supports the assumption that different toxic mechanisms (i.e. excitotoxicity, energy metabolism impairment, inflammatory events, oxidative stress, etc.) are confluent and depend on each other. In this review we will briefly summarize some of those findings and propose a final integrative hypothesis for HD.

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Publishing Authors By Initials

V Perez-De La Cruz,A Santamaria,V Perez-De La Cruz,A Santamaria,V Perez-De La Cruz,A Santamaria,V Perez-De La Cruz,A Santamaria,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 56

Page Numbers: 513-26

Journal Abbreviation:

ISSN: 0862-8408

DAY: 19

MONTH: 12

YEAR: 2006

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9112413

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Integrative hypothesis for Huntington's disease: a brief review of experimental evidence. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.

AFFILIATION: Laboratory of Excitatory Amino Acids, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico. absada@yahoo.com

Country: Czech Republic

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Physiol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Integrative hypothesis for Huntington's disease: a brief review of experimental evidence Related Publications

• After-hours discharge from intensive care: impact on outcome.
• An intensivist-led tracheostomy review team is associated with shorter decannulation time and length of stay: a prospective cohort study.
• Cesariella, a new genus of Laboulbeniales.
• Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.
• Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.
• Colossal ionic conductivity at interfaces of epitaxial ZrO2:Y2O3/SrTiO3 heterostructures.
• Comments on 'the great legalization debate'.
• Contrasting effects of invasive plants in plant-pollinator networks.
• Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats.
• Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells.
• Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.
• Group 13 organoderivatives supported on a metallic oxide model.
• High-level overproduction of Thermus enzymes in Streptomyces lividans.
• How Drosophila change their combs: the Hox gene Sex combs reduced and sex comb variation among Sophophora species.
• Hypophosphatemia as unusual cause of ARDS in Cushing's syndrome secondary to ectopic CRH production. A case report.
• Initial models in conditionals: evidence from priming.
• Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
• Kynurenine pathway and disease: an overview.
• Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder.
• Remifentanil and the brain.
• Report of an EFNS task force on management of sleep disorders in neurologic disease (degenerative neurologic disorders and stroke).
• Soret coefficients in some water-methanol, water-ethanol, and water-isopropanol systems.
• The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling.
• [Carotid angiography; notes on the topographic and histologic diagnosis of cerebral tumors.]
• [In vitro effects of azaserine on normal and neoplastic tissue; polarographic behavior of azaserine.]
• [New derivatives of benzothiazole. I. Synthesis.]
• [New derivatives of benzothiazole. II. Antibacterial action and influence on respiratory systems of animal cells.]
• [Not Available.]
• [Systemic symptoms, cough and cavitated pulmonary nodule in an untreated HIV patient.]
• [The photodynamic properties of thiacoumarin compounds; lethal effects on paramecia and polarographic measurement of photo-oxidation in blood serum.]