Integrative database management for mouse development: systems and concepts.

Integrative database management for mouse development: systems and concepts. Research Abstract Details 

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Integrative database management for mouse development: systems and concepts. Abstract Text:

Amar V Singh,Eric C Rouchka,Greg A Rempala,Caleb D Bastian,Thomas B Knudsen,

Cells in the developing embryo must integrate complex signals from the genome and environment to make decisions about their behavior or fate. The ability to understand the fundamental biology of the decision-making process, and how these decisions may go awry during abnormal development, requires a systems biology paradigm. Presently, the ability to build models with predictive capability in birth defects research is constrained by an incomplete understanding of the fundamental parameters underlying embryonic susceptibility, sensitivity, and vulnerability. Key developmental milestones must be parameterized in terms of system structure and dynamics, the relevant control methods, and the overall design logic of metabolic and regulatory networks. High-content data from genome-based studies provide some comprehensive coverage of these operational processes but a key research challenge is data integration. Analysis can be facilitated by data management resources and software to reveal the structure and function of bionetwork motifs potentially associated with an altered developmental phenotype. Borrowing from applied mathematics and artificial intelligence, we conceptualize a system that can help address the new challenges posed by the transformation of birth defects research into a data-driven science.

Integrative database management for mouse development: systems and concepts. Publishing Authors By Initials

AV Singh,EC Rouchka,GA Rempala,CD Bastian,TB Knudsen,

For similar biological sciences: biology: genetics: pharmacogenetics: toxicogenetics research abstracts see: biological sciences: biology: genetics: pharmacogenetics: toxicogenetics research

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Integrative database management for mouse development: systems and concepts. Journal Published:

PUBLICATION TYPE: Review

Journal: Birth defects research. Part C, Embryo today : rev

VOLUME: 81

Page Numbers: 1-19

Journal Abbreviation: Birth Defects Res. C Embryo To

ISSN: 1542-975X

DAY: 3

MONTH: Mar

YEAR: 2007

Integrative database management for mouse development: systems and concepts. Information

Number of References: 86

LANGUAGE: eng

NlmUniqueID: 101167665

Integrative database management for mouse development: systems and concepts. Keywords Mesh Terms:

KEYWORDS: Toxicogenetics

MESH TERMS: genetics

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Grant and Affiliation Information for Integrative database management for mouse development: systems and concepts.

AFFILIATION: Department of Molecular, Cellular, and Craniofacial Biology, School of Dentistry, University of Louisville, Louisville, Kentucky 40202, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES09120

ACRONYM: ES

MEDLINETA: Birth Defects Res C Embryo Tod

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