Integrating signals between cAMP and MAPK pathways in breast cancer.

Integrating signals between cAMP and MAPK pathways in breast cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Integrating signals between cAMP and MAPK pathways in breast cancer. Abstract Text:

Gabriella Castoria,Antimo Migliaccio,Loredana D'Amato,Rosina Di Stasio,Alessandra Ciociola,Maria Lombardi,Antonio Bilancio,Marina Di Domenico,Antonietta de Falco,Ferdinando Auricchio,Gabriella Castoria,Antimo Migliaccio,Loredana D'Amato,Rosina Di Stasio,Alessandra Ciociola,Maria Lombardi,Antonio Bilancio,Marina Di Domenico,Antonietta de Falco,Ferdinando Auricchio,

Breast cancer is one of the most common malignancies in Western society. Localized breast cancer, before it spreads, can be cured by surgery. However, the high mortality rate associated with breast cancer is due to a propensity of the tumor to metastasize when the primary tumor is small or undetectable. Although steroid receptor status has been recognized as the most precise predictor of response to hormone therapy, a significant number of tumors expressing these receptors metastasize and patients do not respond to the antihormone therapy. The mechanism leading to breast cancer progression and resistance to the hormone therapy is not completely understood at the present time. Compelling evidence shows that hormone-bound steroid receptors in breast cancer cells activate complex signaling networks, which include MAPK- and G protein-dependent pathways. These responses, which occur within seconds or minutes after steroid administration, are not due to changes in gene expression. Depending on cell systems, steroid activation of these networks leads to different and profound effects on extra nuclear and nuclear events. In such a way steroids foster cell cycle, reduce apoptosis and stimulate cell migration of target cells. All these processes are deregulated in breast cancer. In this review we will discuss new aspects of signaling pathways activated by steroids and their integration with other pathways in breast cancer. Recent findings on the discovery of compounds specifically interfering in such a complex network will be presented.

Integrating signals between cAMP and MAPK pathways in breast cancer. Publishing Authors By Initials

G Castoria,A Migliaccio,L D'Amato,R Di Stasio,A Ciociola,M Lombardi,A Bilancio,M Di Domenico,A de Falco,F Auricchio,G Castoria,A Migliaccio,L D'Amato,R Di Stasio,A Ciociola,M Lombardi,A Bilancio,M Di Domenico,A de Falco,F Auricchio,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Integrating signals between cAMP and MAPK pathways in breast cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 13

Page Numbers: 1318-27

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 01

YEAR: 2008

Integrating signals between cAMP and MAPK pathways in breast cancer. Information

Number of References: 85

LANGUAGE: eng

NlmUniqueID: 9709506

Integrating signals between cAMP and MAPK pathways in breast cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Integrating signals between cAMP and MAPK pathways in breast cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Integrating signals between cAMP and MAPK pathways in breast cancer.

AFFILIATION: Department of General Pathology, II University of Naples, Naples, Italy. gabriella.castoria@unina2.it

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Front Biosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Integrating signals between cAMP and MAPK pathways in breast cancer Related Publications

• AAV-mediated gene transfer for retinal diseases.
• Activity monitoring in heart failure patients with cardiac resynchronization therapy.
• Biochemical, Pathological, and Skeletal Improvement of Mucopolysaccharidosis VI After Gene Transfer to Liver but Not to Muscle.
• Comparison of Brain Natriuretic Peptide Plasma Levels Versus Logistic EuroSCORE in Predicting In-Hospital and Late Postoperative Mortality in Patients Undergoing Aortic Valve Replacement for Symptomatic Aortic Stenosis.
• Constitutive and AP20187-induced Ret activation in photoreceptors does not protect from light-induced damage.
• Coronary Sinus Visualization by 3-dimensional Real-time Echocardiography.
• Filamin A is mutated in X-linked chronic idiopathic intestinal pseudo-obstruction with central nervous system involvement.
• Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells.
• In vitro effect of alpha-tocopherol on lysophosphatidylcholine-induced lens damage.
• Influence of left atrial and ventricular volumes on the relation between mitral valve annulus and coronary sinus.
• Inhibition of Estradiol Receptor/Src Association and Cell Growth by an Estradiol Receptor {alpha} Tyrosine-Phosphorylated Peptide.
• Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth.
• Integrating signals between cAMP and MAPK pathways in breast cancer.
• Latent and potential coeliac disease.
• Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy.
• Mankind adaptation and present human health.
• Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors.
• Preferential silencing of a common dominant rhodopsin mutation does not inhibit retinal degeneration in a transgenic model.
• Transglutaminase 1 deficiency and corneocyte collapse: an indication for targeted molecular screening in autosomal recessive congenital ichthyosis.
• Versatility of AAV vectors for retinal gene transfer.
• [Not Available.]
• [Not Available.]