Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes.

Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes. Research Abstract Details 

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Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes. Abstract Text:

We prepared 4 new Zn(II) complexes with Zn(O(4)), Zn(N(2)O(2)), and Zn(S(2)O(2)) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)(2)), bis(alpha-furonic acidato)zinc (Zn(fa)(2)), bis(thiophene-2-carboxylato)zinc (Zn(tc)(2)), and bis(thiophene-2-acetato)zinc (Zn(ta)(2)) complexes were found to be higher than that of zinc sulfate (ZnSO(4)). Zn(ta)(2) showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.

Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes. Publishing Authors By Initials

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Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical & pharmaceutical bulletin

VOLUME: 56

Page Numbers: 1181-3

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 1

MONTH: Aug

YEAR: 2008

Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes. Information

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LANGUAGE: eng

NlmUniqueID: 377775

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Grant and Affiliation Information for Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes.

AFFILIATION: Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University.

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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