Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment.

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Research Abstract Details 

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Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Abstract Text:

Suzanne Craft,

Insulin modulates cognition and other aspects of normal brain function. Insulin resistance is characterized by chronic peripheral insulin elevations, and it is accompanied by reduced brain insulin levels and insulin activity. Obesity, type 2 diabetes mellitus and hypertension are strongly associated with insulin resistance. In addition, insulin resistance increases the risk of age-related memory impairment and Alzheimer's disease. Possible mechanisms through which these risks are increased include the effects of peripheral hyperinsulinemia on memory, CNS inflammation, and regulation of the beta-amyloid peptide. We have shown that raising plasma insulin in humans to levels that characterize patients with insulin resistance increases the levels of Abeta and inflammatory agents in brain. These convergent effects may impair memory and induce AD pathology. Therapeutic strategies focused on preventing or correcting insulin abnormalities may thus benefit a subset of adults with age-related memory impairment and AD.

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Publishing Authors By Initials

S Craft,

For similar nutritional and metabolic diseases: nutrition disorders: overnutrition: obesity research abstracts see: nutritional and metabolic diseases: nutrition disorders: overnutrition: obesity research

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Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Journal Published:

PUBLICATION TYPE: Review

Journal: Current Alzheimer research

VOLUME: 4

Page Numbers: 147-52

Journal Abbreviation:

ISSN: 1567-2050

DAY: 3

MONTH: Apr

YEAR: 2007

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101208441

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Keywords Mesh Terms:

KEYWORDS: Obesity

MESH TERMS: complications

Chemical & Substance for Abstract: Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment.

AFFILIATION: Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. scraft@u.washington.edu

Country: United Arab Emirates

AGENCY: United States NIA

GRANT: R01 AG-10880

ACRONYM: AG

MEDLINETA: Curr Alzheimer Res

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