Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer.

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Abstract Text:

Anna Marie Mulligan,Frances P O'malley,Marguerite Ennis,I George Fantus,Pamela J Goodwin,Anna Marie Mulligan,Frances P O'Malley,Marguerite Ennis,I George Fantus,Pamela J Goodwin,Anna Marie Mulligan,Frances P O'Malley,Marguerite Ennis,I George Fantus,Pamela J Goodwin,

Fasting insulin is related to outcome in early breast cancer. We evaluated the expression of insulin receptor (IR) and its prognostic significance in patients with early stage breast cancer. Tumors from 191 patients with T1-3, N0-1, M0 breast cancer who were enrolled at a single center of a multicenter cohort study were used to construct microarrays with subsequent immunohistochemical evaluation of IR, IGF-IR, ER, PgR and HER2/neu. Correlation of biomarker expression with traditional prognostic factors, serum biochemistry (notably insulin) and clinical outcome was assessed. IR was strongly positive (Allred score = 8) in 54% of tumors. High IR expression significantly correlated with favorable prognostic markers (low tumor grade, lymph node negativity and progesterone receptor positivity) but not with fasting levels of circulating insulin. At a median follow-up of 9.1 years, high vs. low IR expression (an Allred score of 8 vs. 0-7) was associated with statistically significant improved distant disease-free survival (multivariate hazard ratio (HR) = 0.4; P = 0.027) and overall survival (multivariate HR = 0.26; P = 0.005). IR is highly expressed in the majority of early stage breast cancers but this expression is not clearly down-regulated in the presence of high insulin levels. Furthermore, high expression of IR is independently and significantly associated with more favorable clinical outcomes. Follow-up intervention research is recommended.

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Publishing Authors By Initials

AM Mulligan,FP O'malley,M Ennis,IG Fantus,PJ Goodwin,AM Mulligan,FP O'Malley,M Ennis,IG Fantus,PJ Goodwin,AM Mulligan,FP O'Malley,M Ennis,IG Fantus,PJ Goodwin,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Breast cancer research and treatment

VOLUME: 106

Page Numbers: 39-47

Journal Abbreviation: Breast Cancer Res. Treat.

ISSN: 0167-6806

DAY: 13

MONTH: 01

YEAR: 2007

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8111104

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer.

AFFILIATION: Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Breast Cancer Res Treat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer Related Publications

• Ascertainment of Hispanic ethnicity on California death certificates: implications for the explanation of the Hispanic mortality advantage.
• BALANCE: a large simple trial of maintenance treatment for bipolar disorder.
• Conflicting interests and doing right.
• Dupuytren's disease in Oriental Jews.
• Electrochemical detection of harmful algae and other microbial contaminants in coastal waters using hand-held biosensors.
• Environmental tobacco smoke and the epidemic of asthma in children: the role of cigarette use.
• Epidemiology of hepatocellular carcinoma in Hispanics in the United States.
• Factors associated with seven-year incidence of diabetes complications among older Mexican Americans.
• Fatal attraction? The rise of disease management programmes in Europe.
• Impact of osteoarthritis on rehabilitation for persons with hip fracture.
• Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry.
• Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study.
• Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer.
• Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines.
• Intravenous bisphosphonate therapy and inflammatory conditions or surgery of the jaw: a population-based analysis.
• LH and FSH response of Holstein heifers to fertirelin acetate, gonadorelin and buserelin.
• Mortality of foreign-born and US-born Hispanic adults at younger ages: a reexamination of recent patterns.
• OP15.05: Spontaneous intertwin dividing membranes rupture and membranes detachment in twin-twin transfusion syndrome.
• OP24.05: Management of high-order multiples complicated by TRAP sequence.
• Soluble CD44 is a potential marker for the early detection of head and neck cancer.
• Specific phobia and comorbid depression: a closer look at the National Comorbidity Survey data.
• Suicides by violent means in individuals taking SSRIs and other antidepressants: a postmortem study in Sweden, 1992-2004.
• The effect of obesity on disability vs mortality in older Americans.
• The impact of rheumatoid arthritis on rehabilitation outcomes after lower extremity arthroplasty.
• The influence of marital status on stage at diagnosis and survival of older persons with melanoma.
• The relationship between depressive symptoms and shoulder mobility among older women: assessment at one year after breast cancer diagnosis.
• The rise and fall of mood stabilizers.
• The role of the surgeon in whether patients with lymph node-positive colon cancer see a medical oncologist.
• The sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song.
• Trends and disparities in regionalization of pancreatic resection.