Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts.

Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Research Abstract Details 

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Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Abstract Text:

Shelley S Tworoger,I-Min Lee,Julie E Buring,Michael N Pollak,Susan E Hankinson,

Insulin-like growth factor (IGF)-related hormones and binding proteins (IGFBP) have been implicated in cancer risk. Specifically, two recent, small prospective studies reported a significant positive association between IGF-I and ovarian cancer risk among women diagnosed before age 55 years. Therefore, we examined whether plasma concentrations of IGF-I, IGFBP-3, and IGFBP-2 were associated with risk of epithelial ovarian cancer in a nested case-control study using data from three prospective cohorts: the Nurses' Health Study (NHS), NHSII, and the Women's Health Study (WHS). The present study had 222 cases (159 from NHS/NHSII and 63 from WHS) and 599 controls (matching ratio, 1:3 for NHS/NHSII and 1:2 for WHS). Women ranged in age from 34 to 73 years (mean, 56 years). The relative risk (RR) comparing the top versus bottom quartile of IGF-I was 0.56 (95% confidence interval, 0.32-0.97; P(trend) = 0.14). The risk did not differ by age at diagnosis (comparable RR for age <55 years at diagnosis, 0.70; RR for age >/=55 years at diagnosis, 0.52). We did not observe any association between IGFBP-3, IGFBP-2, and the ratio of IGF-I to either binding protein and ovarian cancer risk. Overall, our results do not support a positive association between IGF-related proteins and ovarian cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1691-5).

Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Publishing Authors By Initials

SS Tworoger,IM Lee,JE Buring,MN Pollak,SE Hankinson,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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MEDLINE DATE:

Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1691-5

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Aug

YEAR: 2007

Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: blood

Chemical & Substance for Abstract: Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Information

Substance Name: Insulin-Like Growth Factor I

Registry Number: 67763-96-6

Grant and Affiliation Information for Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts.

AFFILIATION: Channing Laboratory, Department of Medicine, Harvard School of Public Health, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01ES09137

ACRONYM: ES

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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