Insulin is imprinted in the placenta of the marsupial, Macropus eugenii.

Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Research Abstract Details 

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Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Abstract Text:

Eleanor Ager,Shunsuke Suzuki,Andrew Pask,Geoff Shaw,Fumitoshi Ishino,Marilyn B Renfree,Eleanor Ager,Shunsuke Suzuki,Andrew Pask,Geoff Shaw,Fumitoshi Ishino,Marilyn B Renfree,

Therian mammals (marsupials and eutherians) rely on a placenta for embryo survival. All mammals have a yolk sac, but while both chorio-allantoic and chorio-vitelline (yolk sac) placentation can occur, most marsupials only develop a yolk sac placenta. Insulin (INS) is unusual in that it is the only gene that is imprinted exclusively in the yolk sac placenta. Marsupials, therefore, provide a unique opportunity to examine the conservation of INS imprinting in mammalian yolk sac placentation. Marsupial INS was cloned and its imprint status in the yolk sac placenta of the tammar wallaby, Macropus eugenii, examined. In two informative individuals of the eight that showed imprinting, INS was paternally expressed. INS protein was restricted to the yolk sac endoderm, while insulin receptor, IR, protein was additionally expressed in the trophoblast. INS protein increased during late gestation up to 2 days before birth, but was low the day before and on the day of birth. The conservation of imprinted expression of insulin in the yolk sac placenta of divergent mammalian species suggests that it is of critical importance in the yolk sac placenta. The restriction of imprinting to the yolk sac suggests that imprinting of INS evolved in the chorio-vitelline placenta independently of other tissues in the therian ancestor of marsupials and eutherians.

Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Publishing Authors By Initials

E Ager,S Suzuki,A Pask,G Shaw,F Ishino,MB Renfree,E Ager,S Suzuki,A Pask,G Shaw,F Ishino,MB Renfree,

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Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 309

Page Numbers: 317-28

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 27

MONTH: 07

YEAR: 2007

Insulin is imprinted in the placenta of the marsupial, Macropus eugenii. Information

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LANGUAGE: eng

NlmUniqueID: 372762

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Grant and Affiliation Information for Insulin is imprinted in the placenta of the marsupial, Macropus eugenii.

AFFILIATION: Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

Country: United States

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MEDLINETA: Dev Biol

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