Insulin Administration Confers Diabetes-Preventive Properties to NOD Mice Derived Dendritic Cells.

Insulin Administration Confers Diabetes-Preventive Properties to NOD Mice Derived Dendritic Cells. Research Abstract Details 

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Insulin Administration Confers Diabetes-Preventive Properties to NOD Mice Derived Dendritic Cells. Abstract Text:

Ming Xiang,Xiaolei Zou,Chengliang Zhang,Zengyu Zhao,Jing Xu,Ming Xiang,Xiaolei Zou,Chengliang Zhang,Zengyu Zhao,Jing Xu,Ming Xiang,Xiaolei Zou,Chengliang Zhang,Zengyu Zhao,Jing Xu,

Administration of autoantigen can be of value for prevention of autoimmune diabetes and it has been speculated that the control point of dendritic cells (DC) for the induction of peripheral tolerance may be highly relevant. We examined the properties of DC associated with immune suppression in NOD mice by insulin injection subcutaneously and the ability of which to suppress diabetes transfer by diabetogenic effector cells in secondary NOD-SCID recipients. Our data showed that the surface expressions of MHC II and CD86 on NOD-derived DC were increased after insulin treatment compared with those on PBS controlled mice. The dendritic cells with a mature phenotype and increased MLR stimulation adoptively transferred immune tolerogenic effects in secondary NOD-SCID mice, which were associated with significant greater IL-10, TGF-beta production and CD4(+)CD25(+)T differentiation from splenocytes compared with NOD-SCID control recipients. Moreover, treatment with DC remarkably decreased the incidence of diabetes in secondary recipients. These results suggest that a subtype of DC generated by insulin subcutaneous treated NOD mice confers potential protection from diabetes through polarizing the immune response towards a Th2 regulatory pathway.

Insulin Administration Confers Diabetes-Preventive Properties to NOD Mice Derived Dendritic Cells. Publishing Authors By Initials

M Xiang,X Zou,C Zhang,Z Zhao,J Xu,M Xiang,X Zou,C Zhang,Z Zhao,J Xu,M Xiang,X Zou,C Zhang,Z Zhao,J Xu,

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Insulin Administration Confers Diabetes-Preventive Properties to NOD Mice Derived Dendritic Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunopharmacology and immunotoxicology

VOLUME: 29

Page Numbers: 451-64

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ISSN: 0892-3973

DAY: 13

MONTH: 12

YEAR: 2007

Insulin Administration Confers Diabetes-Preventive Properties to NOD Mice Derived Dendritic Cells. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmacology, School of Pharmacy, Tongji Medical College, HuaZhong Science and Technology University, Wuhan, P.R. China.

Country: United States

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MEDLINETA: Immunopharmacol Immunotoxicol

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